Results 31 to 40 of about 14,960 (189)

Genetic Variants of Na+,K+‐ATPase Associated With Neurological Disorders: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Neurological disorders encompass a wide range of severe symptoms and manifestations, many of which are associated with genetic variants that affect ionic homeostasis. Na+,K+‐ATPase, a transmembrane enzyme responsible for maintaining electrochemical gradients in cells, plays a crucial role in neuronal excitability and brain function.
Giovana Kummer da Rosa, Leandro Rodrigo Ribeiro, Jéssica Lorena Bariviera, Mauro Schneider Oliveira   +3 more
wiley   +1 more source

May lamotrigine be an alternative to topiramate in the prevention of migraine with aura? Results of a retrospective study

BMJ Neurology Open, 2020
Background Evidence suggests that lamotrigine could be effective in reducing aura frequency and duration. However, studies comparing lamotrigine to other, first-line prophylactic agents solely involving patients suffering from migraine with aura are ...
Francesco Janes, Carmelo Luca Smeralda, Gian Luigi Gigli, Mariarosaria Valente   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Clinical Pharmacology &Therapeutics, EarlyView.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu   +8 more
wiley   +1 more source

Clinical features of migraine with aura: a REFORM study

The Journal of Headache and Pain
Background About one-third of persons with migraine experience transient neurologic symptoms, referred to as aura. Despite its widespread prevalence, comprehensive clinical descriptions of migraine with aura remain sparse.
Andreas Vinther Thomsen, Håkan Ashina, Haidar M. Al-Khazali, Kathrine Rose, Rune Häckert Christensen, Faisal Mohammad Amin, Messoud Ashina   +6 more
doaj   +1 more source

Effect of migraine on suicide mortality in young adults: a nationwide cohort study in South Korea

BMJ Mental Health
Background Migraine is linked to increased suicidal behaviour, but its relationship with suicide mortality remains underexplored. In South Korea, suicide rates are among the highest in Organisation for Economic Co-operation and Development nations ...
Mi Ji Lee, Kyungdo Han, Dong Wook Shin, Seung Ae Kim   +3 more
doaj   +1 more source

Hemodynamic and tomographic comparisons in patients with migraine

Journal of Education, Health and Sport
A comprehensive clinical and instrumental examination of 104 patients with migraine aged 18 to 44 years was performed using transcranial duplex scanning and magnetic resonance imaging in the groups of patients with migraine without aura (59 patients ...
V. Kalashnikov, R. Vastyanov, O. Stoyanov   +2 more
doaj   +1 more source

Migraine in patients with rheumatoid arthritis and its relation to disease activity

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background The comorbidity between rheumatoid arthritis (RA) and migraine is complex and not completely understood. Objective This study aimed to evaluate migraine frequency in patients with RA and its relation to disease activity.
Hassan Abd-Elaty El-Sonbaty, Carmen Ali Zarad, Mohamed Rezk Mohamed, Ali Ahmed Abou Elmaaty   +3 more
doaj   +1 more source

Could calcitonin gene‐related peptide inhibitors prevent status epilepticus?

Epilepsia, EarlyView.
Abstract Calcitonin gene‐related peptide (CGRP) inhibitors modulate pain and neuroinflammation, a recognized contributor to epileptogenesis and status epilepticus (SE). We examined the association between CGRP inhibitor use and SE hospitalization in epilepsy patients with comorbid migraine.
Michael Nsaka, Noor Baban, Sepideh Allahdadian, Armin Scheffler, Diana Lindner, Dagny Holle, Alain Lekoubou   +6 more
wiley   +1 more source

Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence

Vision, 2021
This review describes the subjective experience of visual aura in migraine, outlines theoretical models of this phenomenon, and explores how these may be linked to neurochemical, electrophysiological, and psychophysical differences in sensory processing ...
Louise O’Hare, Jordi M. Asher, Paul B. Hibbard   +2 more
doaj   +1 more source

Preliminary evidence of long‐term safety and effectiveness of anti‐CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Epilepsia Open, EarlyView.
Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort of adults with comorbid migraine and epilepsy treated with anti‐CGRP ...
Marina Romozzi, Andrea Burgalassi, Francesco Ceriello, Pietro Martino, Giuliano Sette, Francesca Pistoia, Fabio Placidi, Diego Centonze, Luca Pani, Jacopo Canonichesi, Catello Vollono, Paolo Calabresi, Maria Albanese, Luigi Francesco Iannone   +13 more
wiley   +1 more source