Results 1 to 10 of about 575,401 (181)

Inflammatory response of leptomeninges to a single cortical spreading depolarization [PDF]

The Journal of Headache and Pain
Background Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the leptomeninges is less clear.
Anna A. Karan, Konstantin A. Gerasimov, Yulia S. Spivak, Elena M. Suleymanova, Lyudmila V. Vinogradova   +4 more
doaj   +3 more sources

Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine [PDF]

Metabolites, 2022
Metabolite levels in peripheral body fluids can correlate with attack features in migraine patients, which underscores the potential of plasma metabolites as possible disease biomarkers.
Oleg Mayboroda, Inge Loonen, Isabelle Kohler   +2 more
exaly   +4 more sources

Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging [PDF]

Frontiers in Neuroscience, 2022
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related to pathophysiological consequences in numerous neurovascular conditions, including ischemia, traumatic brain injury, cerebral hemorrhage, and migraine ...
Bao-Yu Hsieh, Bao-Yu Hsieh, Yu-Chieh Jill Kao, Ning Zhou, Yi-Pei Lin, Yu-Ying Mei, Sung-Yu Chu, Dong-Chuan Wu   +7 more
exaly   +4 more sources

Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model [PDF]

Neurotherapeutics
This study investigated whether inhaled hydrogen and intrathecal magnesium could mitigate cortical spreading depolarization and delayed cerebral ischemia in a rat model of subarachnoid hemorrhage.
Toru Yoshiura, Satoko Kawauchi, Sho Nishida, Sho Sato, Daichi Hagita, Arumu Endo, Masaya Nakagawa, Takashi Fujii, Yohei Otsuka, Yumiko Mishima, Kazuya Fujii, Satoru Takeuchi, Arata Tomiyama, Terushige Toyooka, Shunichi Sato, Kojiro Wada   +15 more
doaj   +2 more sources

Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization [PDF]

The Journal of Headache and Pain, 2023
Background Migraine headache attacks and accompanying sensory augmentation can be induced by several agents including levcromakalim (LVC), that is also capable of provoking aura-like symptoms in migraineurs.
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Hayrunnisa Bolay, Yildirim Sara   +4 more
doaj   +2 more sources

Effect of lacosamide on cortical spreading depolarization in mice [PDF]

The Journal of Headache and Pain
Background Antiseizure medications are often used as preventive treatment of migraine in appropriate cases; however, the efficacy of lacosamide (LCM), a sodium channel blocker, in preventing migraine attacks remains unclear.
Chisato Iba, Miyuki Unekawa, Keiko Ihara, Yoshikane Izawa, Jin Nakahara, Tsubasa Takizawa   +5 more
doaj   +2 more sources

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization [PDF]

Scientific Reports, 2021
Cortical spreading depolarization (CSD) is a propagating wave of tissue depolarization characterized by a large increase of extracellular potassium concentration and prolonged subsequent electrical silencing of neurons.
Hiromu Monai, Shinnosuke Koketsu, Yoshiaki Shinohara, Takatoshi Ueki, Peter Kusk, Natalie L. Hauglund, Andrew J. Samson, Maiken Nedergaard, Hajime Hirase   +8 more
doaj   +2 more sources

Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice [PDF]

The Journal of Headache and Pain, 2023
Background Cortical spreading depolarization (CSD), the neurophysiological correlate of the migraine aura, can activate trigeminal pain pathways, but the neurobiological mechanisms and behavioural consequences remain unclear. Here we investigated effects
Anisa Dehghani, Maarten Schenke, Sandra H. van Heiningen, Hulya Karatas, Else A. Tolner, Arn M. J. M. van den Maagdenberg   +5 more
doaj   +2 more sources

Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization [PDF]

The Journal of Headache and Pain, 2020
Background Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarization. Sleep disorders are well known
Andrea Negro, Jessica L. Seidel, Thijs Houben, Esther S. Yu, Ike Rosen, Andrea J. Arreguin, Nilufer Yalcin, Lea Shorser-Gentile, Lea Pearlman, Homa Sadhegian, Ramalingam Vetrivelan, Nancy L. Chamberlin, Cenk Ayata, Paolo Martelletti, Michael A. Moskowitz, Katharina Eikermann-Haerter   +15 more
doaj   +2 more sources

Case report: Delayed posttraumatic cortical laminar necrosis secondary to spreading depolarization induced spreading ischemia from old subarachnoid hemorrhage

Radiology Case Reports, 2022
Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported.
Zakariya Irfanullah, Can Ozutemiz, Jetter Robertson   +2 more
exaly   +3 more sources