Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model [PDF]
International Journal of Molecular Sciences, 2021 Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a major health concern that often leads to long-lasting complications.
Jens Dreier +2 more
exaly +3 more sources
Diversity of cortical activity changes beyond depression during Spreading Depolarizations
Nature Communications, 2023 Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in ...
Azat Nasretdinov +8 more
doaj +3 more sources
Caffeine does not affect susceptibility to cortical spreading depolarization in mice [PDF]
Journal of Cerebral Blood Flow and Metabolism, 2019 Several factors that modulate migraine, a common primary headache disorder, also affect susceptibility to cortical spreading depolarization (CSD). CSD is a wave of neuronal and glial depolarization and thought to underlie the migraine aura and possibly ...
Cenk Ayata, Michael Moskowitz
exaly +4 more sources
First FHM3 mouse model shows spontaneous cortical spreading depolarizations [PDF]
Annals of Clinical and Translational Neurology, 2020 Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse ...
Nico A. Jansen +5 more
doaj +2 more sources
Detecting Cortical Spreading Depolarization with Full Band Scalp Electroencephalography: An Illusion? [PDF]
Frontiers in Neurology, 2018 IntroductionThere is strong evidence suggesting detrimental effects of cortical spreading depolarization (CSD) in patients with acute ischemic stroke and severe traumatic brain injury.
Jeannette Hofmeijer +9 more
doaj +2 more sources
Effects of passive smoking on cortical spreading depolarization in male and female mice [PDF]
The Journal of Headache and PainBackground Patients with migraine are typically advised to avoid passive smoking because it may aggravate headaches and other health conditions. However, there is insufficient high-quality evidence on the association between passive smoking and migraine,
Tsubasa Takizawa +15 more
doaj +2 more sources
Heightened Sensitivity of the Hyperexcitable Occipital Cortex to Spreading Depression: Evidence for State-Dependent Mechanisms of Migraine Aura [PDF]
Neurology InternationalBackground/Objectives: Cortical spreading depolarization (SD) is recognized as the pathophysiological substrate of migraine aura. Suppression of ongoing cortical activity produced by SD is thought to underlie the transient neurological deficits ...
Tatiana M. Medvedeva +2 more
doaj +2 more sources
Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia [PDF]
Neurobiology of Disease, 2014 Cortical spreading depolarization (CSD) is known to exacerbate ischemic damage, as the number of CSDs correlates with the final infarct volumes and suppressing CSDs improves functional outcomes.
Yu-Chieh Jill Kao +5 more
doaj +2 more sources
Neuron-derived extracellular vesicles reflect adaptive neuronal responses to cortical spreading depolarization: a biomarker study for migraine [PDF]
The Journal of Headache and PainBackground Small extracellular vesicles (EVs) are nano-sized membranous particles transporting bioactive cargo, including proteins. In the central nervous system (CNS), neuron-derived EVs (nEVs) are thought to play roles in synaptic plasticity, metabolic
Melike Sever-Bahcekapili +9 more
doaj +2 more sources
Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice [PDF]
International Journal of Molecular Sciences, 2022 Yoshikane Izawa +2 more
exaly +2 more sources