Results 1 to 10 of about 10,427 (246)

Spreading Depressions and Periinfarct Spreading Depolarizations in the Context of Cortical Plasticity [PDF]

Neuroscience, 2020
Abstract Studies of cortical function-recovery require a comparison between normal and post-stroke conditions that lead to changes in cortical metaplasticity. Focal cortical stroke impairs experience-dependent plasticity (ExDP) in the neighboring somatosensory cortex and usually evokes periinfarct depolarizations (PiDs) – a spreading ...
Jabłonka, Jan A., Mehlhorn, Clemens, Sadowska, Maria, Średniawa, Władysław, Szewczyk, Łukasz M., Szlachcic, Aleksandra, Urban, Paulina, Winiarski, Maciej   +7 more
openaire   +3 more sources

Migraine preventive drugs differentially affect cortical spreading depression in rat

Neurobiology of Disease, 2011
Cortical spreading depression (CSD) is the most likely cause of the migraine aura. Drugs with distinct pharmacological properties are effective in the preventive treatment of migraine.
Volodymyr Borysovych Bogdanov, Sylvie Multon, Virginie Chauvel, Olena Viktorivna Bogdanova, Dimiter Prodanov, Mykola Yukhymovych Makarchuk, Jean Schoenen   +6 more
doaj   +1 more source

Heightened Sensitivity of the Hyperexcitable Occipital Cortex to Spreading Depression: Evidence for State-Dependent Mechanisms of Migraine Aura

Neurology International
Background/Objectives: Cortical spreading depolarization (SD) is recognized as the pathophysiological substrate of migraine aura. Suppression of ongoing cortical activity produced by SD is thought to underlie the transient neurological deficits ...
Tatiana M. Medvedeva, Maria P. Smirnova, Lyudmila V. Vinogradova   +2 more
doaj   +1 more source

Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis

Neural Regeneration Research, 2017
Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or “enriched environment” as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions
Ryo Tamaki, Samuel Ige Orie, Beat Alessandri, Oliver Kempski, Axel Heimann   +4 more
doaj   +1 more source

Advances in Migraine Mechanisms and Treatment

Pediatric Neurology Briefs, 2004
Migraine mechanisms are discussed in relation to familial hemiplegic migraine (FHM) genotypes by investigators from the Massachusetts General Hospital, Boston, and Universities in Ankara, Turkey.
J Gordon Millichap
doaj   +1 more source

Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway

Nature Communications, 2020
Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and ...
Sarah E. Smith, Xiaoying Chen, Lindsey M. Brier, Jonathan R. Bumstead, Nicholas R. Rensing, Alison E. Ringel, Haewon Shin, Anna Oldenborg, Jan R. Crowley, Annie R. Bice, Krikor Dikranian, Joseph E. Ippolito, Marcia C. Haigis, Thomas Papouin, Guoyan Zhao, Michael Wong, Joseph P. Culver, Azad Bonni   +17 more
doaj   +1 more source

Aura and Head pain: relationship and gaps in the translational models

The Journal of Headache and Pain, 2019
Migraine is a complex brain disorder and initiating events for acute attacks still remain unclear. It seems difficult to explain the development of migraine headache with one mechanism and/or a single anatomical location.
Hayrunnisa Bolay, Doga Vuralli, Peter J. Goadsby   +2 more
doaj   +1 more source

Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura

The Journal of Headache and Pain
Background Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to elicit transient local silencing cortical activity.
Tatiana M. Medvedeva, Maria P. Smirnova, Irina V. Pavlova, Lyudmila V. Vinogradova   +3 more
doaj   +1 more source

Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.
Mariana Séfora Bezerra Sousa, Iasmym Melissa Soares de Holanda, Heloísa Mirelle Costa Monteiro, Ângela Amâncio-dos-Santos   +3 more
doaj   +2 more sources

Susceptibility Weighted Imaging in Migraines with and Without Aura: A Case–Control Study

Neurology International
Background: The asymmetry of cortical veins in susceptibility weighted imaging (SWI) in MRI might be a biomarker for migraine auras and cortical spreading depression (CSD).
Adrian Scutelnic, Tomas Klail, Diego Moor, Nedelina Slavova, Valentina Petroulia, Simon Jung, Mattia Branca, Urs Fischer, Franz Riederer, Roland Wiest, Christoph J. Schankin   +10 more
doaj   +1 more source