Results 31 to 40 of about 10,427 (246)
Data of ascending cortical vein occlusion induced spreading depression
Data in Brief, 2018 The data presented in this article are related to the research article entitled “Microembolism of single cortical arterioles can induce spreading depression and ischemic injury; a potential trigger for migraine and related MRI lesions” (Donmez-Demir et ...
Buket Dönmez-Demir +2 more
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Cortical spreading depression in migraine-time to reconsider?
Arquivos de Neuro-Psiquiatria, 2015 New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of ...
Alan J McComas, Adrian R M Upton
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Neurobiology of Pain, 2022 Migraine is one of the most common pain disorders and causes disability in millions of people every year. Delta opioid receptors (DOR) have been identified as a novel therapeutic target for migraine and other headache disorders.
Zachariah Bertels +6 more
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From “Transient Hemiopsia” to Migraine Aura
Vision, 2021 This paper outlines the historical development of the concept of the visual aura of migraine, from the first comprehensive published description by the physician Hubert Airy, in 1870.
Mark William Weatherall
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Evidence for orexinergic mechanisms in migraine
Neurobiology of Disease, 2015 Objective: To examine the effect of the orexinergic blockade with a dual orexin receptor antagonist (DORA) on experimental models of peripheral and central trigeminal as well as cortical activation relevant to migraine and migraine aura. Methods: In this
Jan Hoffmann +7 more
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Dynamics of Ionic Shifts in Cortical Spreading Depression [PDF]
Cerebral Cortex, 2015 Cortical spreading depression is a slowly propagating wave of near-complete depolarization of brain cells followed by temporary suppression of neuronal activity. Accumulating evidence indicates that cortical spreading depression underlies the migraine aura and that similar waves promote tissue damage in stroke, trauma, and hemorrhage.
Enger, R. +7 more
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The Role of Metabolism in Migraine Pathophysiology and Susceptibility
Life, 2021 Migraine is a highly prevalent and disabling primary headache disorder, however its pathophysiology remains unclear, hindering successful treatment. A number of key secondary headache disorders have headaches that mimic migraine. Evidence has suggested a
Olivia Grech +5 more
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Spinal and cortical spreading depression enhance spinal cord activity
Neurobiology of Disease, 2004 Cortical spreading depression (CSD) has been suggested to underlie some neurological disorders such as migraine. Despite the intensity with which many investigators have studied SD in the brain, only a few studies have aimed to identify SD in the spinal ...
A Gorji +3 more
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Gabapentin Suppresses Cortical Spreading Depression Susceptibility [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2010 Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca v 2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca v 2.1 through ...
Hoffmann, Ulrike +3 more
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A mathematical model for spreading cortical depression
Biophysical Journal, 1978 A mathematical model is derived from physiological considerations for slow potential waves (called spreading depression) in cortical neuronal structures. The variables taken into account are the intra- and extracellular concentrations of Na+, Cl-, K+, and Ca++, together with excitatory and inhibitor transmitter substances.
Tuckwell, H.C., Miura, R.M.
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