Results 41 to 50 of about 1,302,249 (240)
Migraine preventive drugs differentially affect cortical spreading depression in rat
Neurobiology of Disease, 2011 Cortical spreading depression (CSD) is the most likely cause of the migraine aura. Drugs with distinct pharmacological properties are effective in the preventive treatment of migraine.
Volodymyr Borysovych Bogdanov +6 more
doaj +1 more source
Depolarization increases cellular light transmission [PDF]
, 2008 Application of optical methods to human brain tissue in vivo, e.g., measuring oxyhemoglobin and deoxyhemoglobin concentration changes with near-infrared spectroscopy (NIRS), requires the a priori assumption that background optical properties remain ...
Takashi Osada +6 more
core
Sarcoma family kinase activity is required for cortical spreading depression
, 2017 Objectives: Sarcoma family kinase activity is associated with multiple diseases including ischemia and cancer; however, its role in the mechanism of migraine aura has been less well characterised.
John P Quinn +11 more
core +1 more source
The Mind From Within: Visceral Roots of Human Cognition
Advanced Science, EarlyView.The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti +1 more
wiley +1 more source
Dynamics of ionic shifts in cortical spreading depression
, 2015 Cortical spreading depression is a slowly propagatingwave of near-complete depolarization of brain cells followed by temporary suppression of neuronal activity.
Jensen, V. +7 more
core +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Advances in Migraine Mechanisms and Treatment
Pediatric Neurology Briefs, 2004 Migraine mechanisms are discussed in relation to familial hemiplegic migraine (FHM) genotypes by investigators from the Massachusetts General Hospital, Boston, and Universities in Ankara, Turkey.
J Gordon Millichap
doaj +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Nature Communications, 2020 Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and ...
Sarah E. Smith +17 more
doaj +1 more source
Cortical Spreading Depression Impairs Oxygen Delivery and Metabolism in Mice
, 2011 Cortical spreading depression (CSD) is associated with severe hypoperfusion in mice. Using minimally invasive multimodal optical imaging, we show that severe flow reductions during and after spreading depression are associated with a steep decline in ...
Katharina Eikermann-Haerter +6 more
core +1 more source