Mechanisms of initiation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms.
Marina Vitale +4 more
doaj +5 more sources
Estrogen modulation of cortical spreading depression [PDF]
The Journal of Headache and Pain, 2023 Background and aims Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a headache trigger. Migraine
Chiho Kudo +4 more
doaj +5 more sources
Cortical spreading depression and meningeal nociception [PDF]
Neurobiology of Pain, 2022 Migraine results in an enormous burden on individuals and societies due to its high prevalence, significant disability, and considerable economic costs.
Simone Carneiro-Nascimento, Dan Levy
doaj +4 more sources
Mathematical Psychiatry: On Cortical Spreading Depression—A Review [PDF]
Brain Sciences, 2023 The concept of migraine with aura (MwA) is a widespread condition that can affect up to 30% of migraine patients and manifests itself as a temporary visual illusion followed by a prolonged headache. It was initially pitched as a neurological disease, and
Ejay Nsugbe
doaj +2 more sources
Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping [PDF]
Molecular Brain, 2022 Highlights 1. We established an optogenetic mouse CSD model without irritation dura, which could mimic the behaviors of headache and photophobia. 2. It was the first time to depict a broad, unbiased neuronal activity map throughout the mouse brain after ...
Chenghui Pi +8 more
doaj +2 more sources
Migrainous Infarction and Cortical Spreading Depression. [PDF]
Discoveries (Craiova), 2020 Migraine is a very common disorder of the nervous system. It shares similar physiological processes with stroke. Migrainous infarction is a rare complication of migraine with aura. The neuro-logical symptoms of migraine aura correspond to the cortical spreading depression and this depression can lead to a migrainous infarction. It is pertinent to state
Iftikhar W +3 more
europepmc +3 more sources
Metabolic Pathophysiology of Cortical Spreading Depression: A Review [PDF]
Brain SciencesCortical spreading depression (CSD) is an electrophysiologic pathological state in which a wave of depolarization in the cerebral cortex is followed by the suppression of spontaneous neuronal activity.
Arren Hill +12 more
doaj +2 more sources
Inhibition of HSP90 Preserves Blood–Brain Barrier Integrity after Cortical Spreading Depression [PDF]
Pharmaceutics, 2022 Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders, including migraine. Blood–brain barrier (BBB) permeability is increased during CSD.
Seph M. Palomino +5 more
doaj +2 more sources
ROS/TRPA1/CGRP signaling mediates cortical spreading depression [PDF]
The Journal of Headache and Pain, 2019 Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis.
Liwen Jiang +3 more
doaj +2 more sources
Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence [PDF]
Vision, 2021 This review describes the subjective experience of visual aura in migraine, outlines theoretical models of this phenomenon, and explores how these may be linked to neurochemical, electrophysiological, and psychophysical differences in sensory processing ...
Louise O’Hare +2 more
doaj +2 more sources