Results 61 to 70 of about 18,934 (225)

P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine?

, 2002
The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ, Yolande E. Knight, Knight, Yolande E., Knight, YE, Goadsby, Peter J., Bartsch, Thorsten, Peter J. Goadsby, Kaube, Holger, Holger Kaube, Kaube, H, Thorsten Bartsch, Bartsch, T   +11 more
core   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Evaluation of nerve fiber layer and ganglion cell complex changes in patients with migraine using optical coherence tomography

eNeurologicalSci
Purpose: To analyze changes in peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness in migraine patients with and without aura compared to healthy controls and to identify factors influencing the occurrence of these ...
Yasmin Walha, Mona Rekik, Khadija Sonda Moalla, Sonda Kammoun, Omar Ayadi, Chokri Mhiri, Mariem Dammak, Amira Trigui   +7 more
doaj   +1 more source

Cognitive and emotional mechanisms underlying migraine quality of life

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study was conducted to examine how migraine‐related illness perceptions, shame, and psychological distress are associated with migraine‐specific quality of life, and to test a serial mediation model in which illness perceptions relate to quality of life via shame and psychological distress.
Shiri Shinan‐Altman, Yaira Hamama‐Raz   +1 more
wiley   +1 more source

Characteristics of acute ischemic stroke and unusual aura in patients with migraine with aura. [PDF]

BACKGROUND Sometimes migraine aura changes from attack to attack, raising the question of whether the change is heralding an ischemic stroke or an unusual aura.
Scutelnic, Adrian, Arnold, Marcel, Jung, Simon, Beyeler, Morin, Meinel, Thomas R, Fischer, Urs, Riederer, Franz, Mattle, Heinrich P, Sutter, Nathalie L, Schankin, Christoph J   +9 more
core   +1 more source

Causal association between systemic lupus erythematosus and the risk of migraine: A Mendelian randomization study

Brain and Behavior
Background Numerous studies have found that patients with systemic lupus erythematosus (SLE) often have comorbid headache, especially migraine. However, the causal relationship between genetically determined SLE and migraine risk remains unclear ...
Meixuan Ren, Hangtian Yu, Bing Xiao, Yan Zhao, Jiewei Yan, Jianghong Liu   +5 more
doaj   +1 more source

A study on the therapeutic effects of Topiramate according to the types of migraine [PDF]

Korean Journal of Pediatrics, 2010
Purpose : The purpose of this study was to evaluate whether the therapeutic effects of topiramate differ according to the types of migraine. Methods : We recruited 38 children and adolescents with migraine who had been treated with topiramate. The effect
Jun Hwa Lee, Kyung Lae Cho
doaj   +1 more source

Podcast‐induced reflex seizures: A unique trigger

Epileptic Disorders, EarlyView.
David W. Cao, Roberto Gonzalez, Irfan S. Sheikh, Melissa Huynh Mabry   +3 more
wiley   +1 more source

Effectiveness of galcanezumab versus topiramate, amitriptyline, and other select traditional oral migraine preventives with evidence of efficacy: 3‐Month results from the TRIUMPH study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To compare the 3‐month effectiveness of galcanezumab with select traditional oral migraine preventive (TOMP) medications recommended by scientific societies (TOMP efficacy subset) and with the most frequently used individual TOMP medications.
Shivang Joshi, Cristina Tassorelli, Manjit Matharu, Taoufik Alsaadi, Carlos Vallarino, Lars Viktrup, Maurice Vincent, Rebecca L. Robinson   +7 more
wiley   +1 more source

Selectivity in genetic association with sub-classified migraine in women. [PDF]

PLoS Genetics, 2014
Migraine can be sub-classified not only according to presence of migraine aura (MA) or absence of migraine aura (MO), but also by additional features accompanying migraine attacks, e.g. photophobia, phonophobia, nausea, etc.
Daniel I Chasman, Verneri Anttila, Julie E Buring, Paul M Ridker, Markus Schürks, Tobias Kurth, International Headache Genetics Consortium   +6 more
doaj   +1 more source