Results 91 to 100 of about 2,963,459 (334)

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Inflammo-immune perspective on the association of eight migraine risk factors with migraine: a multi-omics Mendelian randomization study

Frontiers in Neurology
BackgroundMigraine risk factors are associated with migraine susceptibility, yet their mechanisms are unclear. Evidence suggests a role for inflammatory proteins and immune cells in migraine pathogenesis.
Jiaxi Zhao, Rong Chen, Mengqi Luo, Hongping Gong, Kaixin Li, Kaixin Li, Qian Zhao   +6 more
doaj   +1 more source

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

The Journal of Headache and Pain, 2019
Background Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migraine.
Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello, Gianluca Serafini, on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)   +11 more
doaj   +1 more source

COMORBIDITY OF MIGRAINE AND PSYCHIATRIC DISORDERS

Neurologic Clinics, 1997
This article reviews the evidence for comorbidity of migraine with psychiatric disorders, particularly the affective and anxiety disorders. Studies of the association between migraine and depression in both clinical and community studies have provided consistent evidence regarding a substantial degree of comorbidity between these disorders, regardless ...
Kathleen R. Merikangas, Denise E. Stevens   +1 more
openaire   +3 more sources

Migraine headache: Is it only a neurological disorder? Links between migraine and cardiovascular disorders

Trends in Cardiovascular Medicine, 2020
Migraine headache (MH) is a common disorder affecting millions of people in the United States. MH is substantially more prevalent in women compared to men. An association between migraine with or without aura and risk of cardiovascular disease (CVD) has been extensively reported. There are several proposed theories that may explain the pathophysiologic
Dandan Chen, Monica Willis-Parker, Gina Price Lundberg   +2 more
openaire   +3 more sources

Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The patent foramen ovale (PFO), present in 25% of the population, can cause paradoxical embolism and stroke. Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter‐atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy.
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Georgios Tzimas, Ioannis Skalidis, David Meier, Panagiotis Antiochos, Panagiotis Kostakis, Efthymia Pavlou, Francesco Perone, Georgios Tsivgoulis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis   +13 more
wiley   +1 more source

Factors associated with acute medication overuse in chronic migraine patients [PDF]

Einstein (São Paulo), 2012
Objective: To evaluate the prevalence of psychiatric disorders inpatients diagnosed with chronic migraine with and without acutemedication overuse. Methods: Seventy-two volunteers were recruitedfrom a Family Health Program of the Paraisópolis community ...
Vera Zukerman Guendler, Juliane Prieto Peres Mercante, Reinaldo Teixeira Ribeiro, Eliova Zukerman, Mario Fernando Prieto Peres   +4 more
doaj  

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Continuing medical education in epileptology: The Level 1‐2‐3 experience of the ILAE academy

Epileptic Disorders, EarlyView.
Abstract The International League Against Epilepsy (ILAE) Academy is the world's eminent e‐learning campus for epileptology. Its modular teaching content was developed to cover all competencies and learning objectives specified in the ILAE's curriculum for epileptology.
Ingmar Blümcke, Eva Biesel, Samuel Wiebe, Sandor Beniczky, Jo M. Wilmshurst, Man Mohan Mehndiratta, Ali A. Asadi‐Pooya, Christian Brandt, Alexis Arzimanoglou, Gagandeep Singh, on behalf of the ILAE Academy content development faculty, Raidah Al Baradie, Carmen Barba, Jocelyn F. Bautista, Sallie Baxendale, Elena Belousova, Isabella Brambilla, Jorge G. Burneo, Leonor Cabral‐Lim, Jaime Carrizosa, Jaume Campistol, Hannah Cock, Marion Comajuan, Helen Cross, Emilija Cvetkovska, Valentina De Giorgis, Luca De Palma, Kirsten A. Donald, Georg Dorfmüller, Guadalupe Fernandez Baca Vaca, Jessica Fesler, Irene García Morales, Christina Giavasi, Maria Gogou, Patricia Gómez Iglesias, Samson Gwer, Till Hartlieb, Martin Holtkamp, Floor E. Jansen, Bosanka Jocic‐Jakubi, Philippe Kahane, Ioannis Karakis, Takafumi Kubota, Joshua Laing, Tatjana Liakina, Aileen McGonigal, Rosa Michaelis, Ioana Mindruta, Andrew Neal, Maureen Njoroge, Irina Oane, Terence O’Brien, Finbar O’Callaghan, Manuela Ochoa Urrea, Nicholas Odero, Sebastián Ortiz, Karine Ostrowsky‐Coste, Maria T. Papadopoulou, Tiziana Pisano, Anna Rada, Stefan Rampp, Markus Reuber, Sylvain Rheims, Andrea O. Rossetti, Guido Rubboli, Victoria San Antonio‐Arce, Jan‐Christoph Schoene‐Bake, Artem Sharkov, Hugh D. Simpson, Mary Lou Smith, Ana Suller Marti, Rainer Surges, Roland Thijs, Joseph Toulouse, Bart van den Munckhof, Bernd J. Vorderwülbecke, Alistair Wardrope, Peter Wolf, Elza Márcia Yacubian   +78 more
wiley   +1 more source