Results 171 to 180 of about 69,866 (217)

Peripheral targets for neuropathic pain

open access: yesBritish Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour   +3 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Vertigo and dizziness syndromes in children and adolescents: Clinical presentation and diagnostic pathway

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
This study characterized 519 children and adolescents with vertigo using clinical, diagnostic, imaging, quality‐of‐life, and demographic data, identifying vestibular migraine as the most frequent diagnosis, followed by functional dizziness and recurrent vertigo of childhood.
Doreen Huppert   +7 more
wiley   +1 more source

Neuropsychiatric Outcomes Associated With GLP‐1 Receptor Agonist Use in Medicare Beneficiaries With Type 2 Diabetes: Variation by Treatment Pattern and Obesity Status

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptors are expressed in brain regions governing mood, reward and stress, yet the neuropsychiatric effects of GLP‐1 receptor agonist (GLP‐1 RA) therapy remain poorly characterized. We estimated associations between GLP‐1 RA use and neuropsychiatric disorders and variation by obesity status and treatment ...
Seo Hyon Baik   +4 more
wiley   +1 more source

Cognitive and emotional mechanisms underlying migraine quality of life

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study was conducted to examine how migraine‐related illness perceptions, shame, and psychological distress are associated with migraine‐specific quality of life, and to test a serial mediation model in which illness perceptions relate to quality of life via shame and psychological distress.
Shiri Shinan‐Altman   +1 more
wiley   +1 more source

Real‐world outcomes of zavegepant use in a tertiary care setting using the Migraine Treatment Optimization Questionnaire‐5

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background The introduction of calcitonin gene‐related peptide antagonists has transformed migraine care. Zavegepant, a third‐generation intranasal gepant, offers a nonoral treatment option for acute migraine. Although clinical trials support its efficacy and safety, real‐world data are limited.
Eric Dunn   +5 more
wiley   +1 more source

Three decades of research on the association between temporomandibular disorders and headache: A bibliometric analysis

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives To perform a bibliometric analysis of the scientific literature published over the past 3 decades on the relationship between temporomandibular disorders (TMDs) and headache, examining scientific production, citation impact, and the conceptual structure and temporal evolution of research topics in this field. Background TMDs are the
Tatiana P. da Fonte   +6 more
wiley   +1 more source

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