Results 101 to 110 of about 18,405 (235)

Suzetrigine as a novel treatment for headache disorders: A case series

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Suzetrigine is a selective voltage‐gated sodium channel blocker that was recently approved by the US Food and Drug Administration for the treatment of acute pain. We retrospectively evaluated the efficacy and tolerability of suzetrigine for the treatment of different headache disorders in patients refractory to standard treatments in an ...
Molly Fensterwald, Jordan Johnson, Angel Moreno, Shawn Conger‐Love, Charles Flippen, Chelsea Hesterman, Mollie Johnston, Joshua Kamins, Karla Minota, Peony Pak, Salman Hashim, Thanh‐Liem Huynh‐Tran, Noelle Kobayashi, Bradley Shane, Andrew Charles, Sinifunanya Nwaobi   +15 more
wiley   +1 more source

ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura

The Journal of Headache and Pain, 2020
Background In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society.
Carl H. Göbel, Sarah C. Karstedt, Thomas F. Münte, Hartmut Göbel, Sebastian Wolfrum, Elena R. Lebedeva, Jes Olesen, Georg Royl   +7 more
doaj   +1 more source

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

, 2010
Migraine with aura is a common, debilitating, recurrent headache disorder associated with transient and reversible focal neurological symptoms. A role has been suggested for the two-pore domain (K2P) potassium channel, TWIK-related spinal cord potassium ...
Lafrenière, Ronald, Ebers, G, Brais, B, Marcinkiewicz, Martin M, Stephen J Tucker, Rouleau, Guy, Griffiths, Lyn, Lyn R Griffiths, Bernard Brais, Griffiths, Lyn R., Ebers, George, Jean-François Poulin, Tucker, Stephen J., Brais, Bernard, Cader, M Zameel, Isabelle Andres-Enguix, Lafrenière, F, Jorge Sequeiros, Maryse Simoneau, Cader, MZ, Dubé, Marie-Pierre, Sreeram Ramagopalan, Ramagopalan, Sreeram, Gupta, N, Guy A Rouleau, Cader, Muhammed, Poulin, JF, Marcinkiewicz, Martin, Boisvert, K, Olaf Ansorge, Griffiths, LR, Lafrenière, François, McLaughlan, S, Tucker, Stephen, François Lafrenière, Andres-Enguix, Isabelle, Boisvert, Karine, Jose Maria Pereira-Monteiro, M Zameel Cader, Rouleau, GA, Ansorge, Olaf, Griffiths, Lyn R, Poulin, Jean-François, Sequeiros, J, Marie-Pierre Dubé, Simoneau, Maryse, Rouleau, Guy A., Martin M Marcinkiewicz, Ansorge, O, Lafrenière, Ronald G, Tucker, SJ, Dubé, MP, Simoneau, M, Andres-Enguix, I, Karine Boisvert, Shannon McLaughlan, Ramagopalan, S, Lafrenière, RG, Marcinkiewicz, MM, Gupta, Namrata, Pereira-Monteiro, Jose Maria, Tucker, Stephen J, Pereira-Monteiro, JM, Ronald G Lafrenière, Rouleau, Guy A, Sequeiros, Jorge, Namrata Gupta, McLaughlan, Shannon, George Ebers   +68 more
core   +1 more source

Typical Lateral Interactions, but Increased Contrast Sensitivity, in Migraine-With-Aura [PDF]

, 2018
Individuals with migraine show differences in visual perception compared to control groups. It has been suggested that differences in lateral interactions between neurons might account for some of these differences.
Jordi Asher, Louise O’Hare, Vincenzo Romei, Hibbard, PB, O’Hare, Louise, Hibbard, Paul, O'hare L., Paul B. Hibbard, O'Hare, L, Romei, Vincenzo, Romei V., Asher, JM, Jordi M. Asher, Paul Hibbard, Hibbard P. B., Asher, Jordi, Asher J. M., Romei, V   +17 more
core   +1 more source

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source

Presence of vestibular symptoms and related disability in migraine with and without aura and chronic migraine

, 2018
ObjectiveTo assess the presence and handicap due to vestibular symptoms in three subgroups of patients with migraine and controls.MethodsWomen between 18–55 years old were diagnosed by headache specialists and stratified as migraine with aura (n = 60 ...
Gabriela F Carvalho, Carina F Pinheiro, Flávia Heck Vianna-Bell, Carvalho, Gabriela F., Vianna-Bell, Flávia H., Marcelo E Bigal, Debora Bevilaqua-Grossi, Bigal, Marcelo E., Lidiane L Florencio, Dach, Fabíola, Florêncio, Lidiane L., Bevilaqua-Grossi, Débora, Fabiola Dach, Pinheiro, Carina F.   +13 more
core   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses for Ubrogepant Efficacy and Safety in the Acute Treatment of Migraine: Analysis of Phase 1–3 Studies

The Journal of Clinical Pharmacology, Volume 66, Issue 6, June 2026.
Abstract A population pharmacokinetic (popPK) model was developed for ubrogepant using data from 10 Phase 1, 1 Phase 2, and 2 Phase 3 studies. The data were described by a 2‐compartment model with linear elimination and transit compartment absorption. Formulation, food intake, race, gender, and hepatic impairment had a statistically significant impact ...
Sven Stodtmann, Lucia Siovitz, Heiko Babel, Ramesh R. Boinpally   +3 more
wiley   +1 more source

Signatures of migraine aura in high-density-EEG.

OBJECTIVE Cortical spreading depolarization is highly conserved among the species. It is easily detectable in direct cortical surface recordings and has been recorded in the cortex of humans with severe neurological disease.
Scutelnic, Adrian, Schankin, Christoph, Beiersdorf, Johannes, Baumgartner, Christoph, Lang, Clemens, Riederer, Franz, Platho-Elwischger, Kirsten, Klein, Antonia, Dreier, Jens P, Pirker-Kees, Agnes   +9 more
core   +1 more source

What's Needed for a Migraine Cost‐Of‐Illness Study in Aotearoa New Zealand: Review of Data Sources and Gaps

Journal of the Royal Society of New Zealand, Volume 56, Issue 3, June 2026.
Cost of illness (COI) studies are used to quantify the economic burden of disease on health systems, employers and society, and identify where costs may be saved by improvements in disease management. Many migraine COI studies have been published internationally but none have included data from Aotearoa New Zealand (NZ), despite the known high ...
Fiona Imlach, Sofiia Tsaregorodtseva, Maite Irurzun‐Lopez, William Leung, Calvin Chan, Ray Bose   +5 more
wiley   +1 more source

Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology

, 2009
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
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