Results 21 to 30 of about 66,422 (218)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A case study of partnership in practice: challenges and insights in the development of an academic-community coalition “The Migrant Health Community Research Network”

Research Involvement and Engagement
Background Participatory research (PR) approaches are increasingly prioritised globally, particularly in the UK, where many funders have emphasised meaningful collaboration with those with lived experience to improve health research relevance ...
Jessica Carter, Felicity Knights, Yusuf Ciftci, Kathryn Mackey, Eltayeb Hassan, Ada Jusic, Isra Al-Sharabi, Anna Deal, Nuria Sanchez Clemente, Alison Crawshaw, Sally E. Hayward, Darlington Faijue, Nathaniel Aspray, Natalie Elkhier, Philippa Harris, Rosita Chia-Yin Lin, Beatriz Morais, Sarah Tizzard, Oumnia Bouaddi, Farah Seedat, Sally Hargreaves   +20 more
doaj   +1 more source

How can we improve migrant health checks in UK primary care: ‘Health Catch-UP!’ a protocol for a participatory intervention development study

BMJ Open
Introduction Global migration has steadily risen, with 16% of the UK population born abroad. Migrants (defined here as foreign-born individuals) face unique health risks, including potential higher rates and delays in diagnosis of infectious and non ...
Azeem Majeed, Sarah Tonkin-Crine, Felicity Knights, Farah Seedat, Rebecca Hall, Sally Hargreaves, Tess Harris, Jessica Carter, Dominik Zenner, Anna Deal, Ana Requena Mendez, Yusuf Ciftci, Nuria Sanchez-Clemente, Philippa Harris, Janet Alfred, Kathryn Mackey, Eltayeb Hassan, Jose Trueba, Nimal Jayawardhena, Isra Al-Sharabi, Nathaniel Aspray, Subash Jayakumar   +21 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Health Catch-UP!: a realist evaluation of an innovative multi-disease screening and vaccination tool in UK primary care for at-risk migrant patients

BMC Medicine
Background Migrants to the UK face disproportionate risk of infections, non-communicable diseases, and under-immunisation compounded by healthcare access barriers.
Jessica Carter, Lucy P. Goldsmith, Felicity Knights, Anna Deal, Subash Jayakumar, Alison F. Crawshaw, Farah Seedat, Nathaniel Aspray, Dominik Zenner, Philippa Harris, Yusuf Ciftci, Fatima Wurie, Azeem Majeed, Tess Harris, Philippa Matthews, Rebecca Hall, Ana Requena-Mendez, Sally Hargreaves   +17 more
doaj   +1 more source

Precarity, agency and trust: Vaccination decision-making in the context of the UK asylum system

SSM: Qualitative Research in Health
Background: Individuals living in initial asylum accommodation are at increased risk of vaccine-preventable disease, yet confidence in vaccination may be low in these settings.
Anna Deal, Maha Salloum, Sally E. Hayward, Alison F. Crawshaw, Felicity Knights, Jessica Carter, Isra Al-Sharabi, Reem Yahia, Stephanie Fisher, Beatriz Morais, Oumnia Bouaddi, Lucy Jones, Anna Miller, Sandra Mounier-Jack, Sally Hargreaves   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Factors influencing malnutrition among adolescent girls in The Gambia: a mixed-methods exploratory study

BMC Public Health
Background In The Gambia, existing research to understand and address malnutrition among adolescent girls is limited. Prior to the conduct of large-scale studies, formative research is needed.
Haddy Jallow-Badjan, Tanefa A. Apekey, Maria J. Maynard   +2 more
doaj   +1 more source

Migrant Health Country Profile tool (MHCP-t) for transforming health data collection and surveillance in the Middle East and North African (MENA) region: tool development protocol with embedded process evaluation

BMJ Open
Introduction The Middle East and North Africa (MENA) region is characterised by major health disparities and complex migration flows. Yet, because of a lack of epidemiological data, there is an urgent need to strengthen routine data collection around ...
Farah Seedat, Bouchra Assarag, Kolitha Wickramage, Sally Hargreaves, Ana Requena-Mendez, Dominik Zenner, Anna Deal, Stella Evangelidou, Oumnia Bouaddi, Moudrick Abdellatifi, Hassan Edries, Eman Elafef, Taha Maatoug, Anissa Ouahchi, Sara Arias, Adel Abdelkhalek, Ibrahim Ahmed Bani, Kenza Hassouni, Mahmoud Hilali, Mohamed Khalis, Wejdene Mansour, Ali Mtiraoui, Hassan Chrifi, Mohamed Douagi, Abdedayem Khelifi   +24 more
doaj   +1 more source