Results 81 to 90 of about 531,325 (290)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Migrant Youths‘ Educational Achievement: The Role of Institutions [PDF]

We use 2009 Programme of International Student Assessment (PISA) data to link institutional arrangements in OECD countries to the disparity in reading, math, and science test scores for migrant and native-born students.
Deborah A. Cobb-Clark, Mathias Sinning, Steven Stillman   +2 more
core   +3 more sources

Adverse health outcomes among migrant workers and transnational families in the Asia–Pacific: a systematic review and meta-analysisResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: Labour migration is a growing global phenomenon, with migrant workers known to be more likely to experience exploitative and precarious work, impacting their health. Despite hosting over 27 million international migrant workers, the
Rosita Chia-Yin Lin, Karen Lau, Kathryn Mackey, Natasha Roya Matthews, Maushmi Selvamani, Morais Beatriz, Bouaddi Oumnia, Chaelin Kim, Azusa Iwamoto, Masami Fujita, Ursula Trummer, Tran Ngoc Dang, Alena Kamenshchikova, Cathy Zimmerman, Sally Hargreaves   +14 more
doaj   +1 more source

Migrant Capital: Networks, Identities and Strategies [PDF]

, 2015
Migrant Capital presents state-of-the-art empirical, theoretical and methodological perspectives on migration, networks, social and cultural capital, exploring the ways in which these bodies of literature can inform and strengthen each other. In so doing,

core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Infrastructural familiarity: How Russian-speaking migrants are expected to become active participants in navigating UK vaccination programmes

SSM: Qualitative Research in Health
International migrants remain an under-immunised group globally. Understanding expectations that national public health infrastructures pose upon newly arrived migrants is crucial for unpacking the challenges that migrants face when seeking vaccination ...
A. Kamenshchikova, A. Deal, J. Carter, F. Knights, O. Bouaddi, N. Aspray, S. Bojang, F. Seedat, N. Sanchez-Clemente, A. Jachmann, S. Hargreaves   +10 more
doaj   +1 more source

Reproductive behaviour of migrant women in Germany: Data, patterns and determinants [PDF]

This paper examines the fertility of female migrants in Germany. After introducing major hypotheses on migrant fertility we give an overview on German datasets that are available for migrant fertility research.
Martin Kohls, Susanne Schmid
core   +1 more source