Results 61 to 70 of about 66,422 (218)

Infrastructural familiarity: How Russian-speaking migrants are expected to become active participants in navigating UK vaccination programmes

SSM: Qualitative Research in Health
International migrants remain an under-immunised group globally. Understanding expectations that national public health infrastructures pose upon newly arrived migrants is crucial for unpacking the challenges that migrants face when seeking vaccination ...
A. Kamenshchikova, A. Deal, J. Carter, F. Knights, O. Bouaddi, N. Aspray, S. Bojang, F. Seedat, N. Sanchez-Clemente, A. Jachmann, S. Hargreaves   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

El perfil del migrante Francés a México a mediados del siglo XIX

Cahiers des Amériques Latines, 2004
This article treats flows of the French migrants towards Mexico with the XIXth century. The analysis, which rests on the rich person documentation of obtaining the passports releases the sociological profile of the migrant fraçais. Contrary to the a long
Chantal Cramaussel
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

International migrant workers, heat exposure, and climate change: a systematic review of health risks and protective interventions

BMC Global and Public Health
Background International migrant workers, representing 170 million people globally, often face hazardous working conditions, including extreme heat exposure.
Lara Van der Horst, Oumnia Bouaddi, Sarah Williams, Meg Jago, Karen Lau, Ben Furber, Amirah Zafirah Zaini, Engy Mohamed El-Ghitany, Tharani Loganathan, Andreas D. Flouris, Davide J. Testa, Cathy Zimmerman, Sally Hargreaves, Consortium for Migrant Worker Health   +13 more
doaj   +1 more source

Neither here nor there: exploring the transnational identity of West African migrants living in South Africa

Acta Academica, 2022
Xenophobia as a form of othering manifests differently in varying contexts, and against the backdrop of globalisation, the nature of migration and societal integration of foreigners has changed over time.
Ijeoma Opara
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Migration, Urbanism and Health: Moving Toward Systems-Informed Policy and Practice [version 2; peer review: 1 approved, 2 approved with reservations]

F1000Research
Migration and displacement are pivotal determinants of urban health, influencing both direct and indirect health outcomes. Migrants may face unique health risks, often exacerbated by economic, social, and environmental factors encountered during transit ...
Karen Lau, Furio Honsell, Sally Hargreaves, Rita Sà Machado, Palmira Immordino, Cathy Zimmerman, Anna Ziersch, Yang Xiao, Irene Torres, Stefania Pascut   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source