Results 51 to 60 of about 66,422 (218)

Multi-infection screening for migrant patients in UK primary care: Challenges and opportunities

Journal of Migration and Health
Background: Migrants in Europe face a disproportionate burden of undiagnosed infection, including tuberculosis, blood-borne viruses, and parasitic infections and many belong to an under-immunised group.
Jessica Carter, Felicity Knights, Anna Deal, Alison F Crawshaw, Sally E Hayward, Rebecca Hall, Philippa Matthews, Farah Seedat, Yusuf Ciftci, Dominik Zenner, Fatima Wurie, Ines Campos-Matos, Azeem Majeed, Ana Requena-Mendez, Sally Hargreaves   +14 more
doaj   +1 more source

SCOPING REVIEW ON MENTAL HEALTH AND CHILD PROTECTIVE SERVICES OF MIGRATED AND REFUGEE CHILDREN AND YOUTH [PDF]

Psychiatria Fennica, 2023
One of the long-term consequences related to migration due to wars, violence, and ecological and climate crises is the additional challenges to the health and child welfare systems in the host country.
Siiri-Liisi Kraav, Natalie Joubert, Merja Anis, Janet Anand, Maili Malin, Max Karukivi, Tommi Tolmunen   +6 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Co‐designing a theory‐informed, multicomponent intervention to increase vaccine uptake with Congolese migrants: A qualitative, community‐based participatory research study (LISOLO MALAMU)

Health Expectations
Introduction Disparities in the uptake of routine and COVID‐19 vaccinations have been observed in migrant populations, and attributed to issues of mistrust, access and low vaccine confidence.
Alison F. Crawshaw, Lusau M. Kitoko, Sarah L. Nkembi, Laura M. Lutumba, Caroline Hickey, Anna Deal, Jessica Carter, Felicity Knights, Tushna Vandrevala, Alice S. Forster, Sally Hargreaves   +10 more
doaj   +1 more source

Workplace mortality risk and social determinants among migrant workers: a systematic review and meta-analysis

The Lancet Public Health
Summary: Background: Migrant workers, a population of 170 million, often work in dangerous or unhealthy working environments and are likely to suffer workplace injuries and labour abuses.
Karen Lau, MSc, Robert Aldridge, ProfPhD, Marie Norredam, ProfPhD, George Frederick Mkoma, PhD, Mathura Kugan, MSc, Rosita Chia-Yin Lin, MSc, Ligia Kiss, PhD, Cathy Zimmerman, ProfPhD, Sally Hargreaves, ProfPhD   +8 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Adverse health outcomes among migrant workers and transnational families in the Asia–Pacific: a systematic review and meta-analysisResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: Labour migration is a growing global phenomenon, with migrant workers known to be more likely to experience exploitative and precarious work, impacting their health. Despite hosting over 27 million international migrant workers, the
Rosita Chia-Yin Lin, Karen Lau, Kathryn Mackey, Natasha Roya Matthews, Maushmi Selvamani, Morais Beatriz, Bouaddi Oumnia, Chaelin Kim, Azusa Iwamoto, Masami Fujita, Ursula Trummer, Tran Ngoc Dang, Alena Kamenshchikova, Cathy Zimmerman, Sally Hargreaves   +14 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source