Results 41 to 50 of about 11,978,086 (252)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Child Health and Migrant Parents in South-East Asia [PDF]

, 2014
This special issue represents findings from a major research project investigating health and migrant parents in South-East Asia (CHAMPSEA).

core   +2 more sources

Migrants’ mental health recovery in Italian reception facilities

Communications Medicine, 2023
Background Forced migration leaves deep marks on the psychological well-being of migrants, with post-traumatic stress disorder (PTSD) and other psychological conditions being prevalent among them.
Emanuele Caroppo, Carmela Calabrese, Marianna Mazza, Alessandro Rinaldi, Daniele Coluzzi, Pierangela Napoli, Martina Sapienza, UOC Salute Mentale working group, Maurizio Porfiri, Pietro De Lellis   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Factors influencing the health-seeking behavior of Vietnamese migrants in Japan: a cross-sectional study on knowledge, attitudes, and practices towards tuberculosis

Tropical Medicine and Health
Background Addressing tuberculosis (TB) among migrants from high-burden countries is important for the health of migrants and for public health in low-TB-burden countries.
Sangnim Lee, Nhan Nguyen Huu Thanh, Yusuke Akutsu, Yoshihisa Shirayama, Pham Nguyen Quy, Jin Takasaki, Akihiro Ohkado   +6 more
doaj   +1 more source

Multi-infection screening for migrant patients in UK primary care: Challenges and opportunities

Journal of Migration and Health
Background: Migrants in Europe face a disproportionate burden of undiagnosed infection, including tuberculosis, blood-borne viruses, and parasitic infections and many belong to an under-immunised group.
Jessica Carter, Felicity Knights, Anna Deal, Alison F Crawshaw, Sally E Hayward, Rebecca Hall, Philippa Matthews, Farah Seedat, Yusuf Ciftci, Dominik Zenner, Fatima Wurie, Ines Campos-Matos, Azeem Majeed, Ana Requena-Mendez, Sally Hargreaves   +14 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Occupational health and safety of migrant sex workers in New Zealand [PDF]

, 2013
This research provides an in-depth understanding of issues facing migrant sex workers in New Zealand, with a particular focus on occupational health and safety, and sexual reproductive health.
Michael Roguski
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source