Results 131 to 140 of about 705,445 (342)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Chapter 8 Western Migrants in Hong Kong: Neo-Imperial Gothic and the Literary Imagination of Reverse Domination [PDF]
, 2023 Kai Wiegandt
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
"On a Variation in the Economic Performance of Migrants by their Home Country's Wage" [PDF]
Although the economic performance of migrants in the receiving country undoubtedly depends on qualifications, it is also affected by inclinations. Given the probability of return migration, a behavioural link is established between the incentive of ...
Stark, Oded
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Dissociation as a mechanism of psychological defense in adapting to a different cultural environment
Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018 In the theoretical part, the authors focus on specific issues in the diagnosis and treatment of patients migrants with dissociative symptoms related to the cultural specialty of the settings in the etiology of emerging symptoms and for psychotherapeutic ...
N. A. Bokhan +2 more
doaj
Why stop there? Mexican migration to the U.S. border region [PDF]
The transformation of the U.S. border economy since the 1980s provides a fascinating backdrop to explore how migration to the U.S-side of the Mexican border has changed vis-a-vis migration to the U.S. interior.
Leslie Lukens +2 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Journal of Modern ScienceObjectives The contribution aims to carry out a socio-anthropological and juridical analysis of the issues concerning the status of migrants and refugees, in order to identify the strategies prepared by the Italian State regarding the protection of the ...
Salvatore Piliu
doaj +1 more source