Results 21 to 30 of about 70,611 (199)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Migrants, Irregular Migrants, or (Irregular) Migrants?

Anti-Trafficking Review, 2018
Response to the ATR Debate Proposition: ‘It is important and necessary to make clear distinctions between (irregular) migrants, refugees and trafficked persons.’ Upon first reading this issue’s debate proposition, I was struck by its structure rather ...
Katharine T. Weatherhead
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

How do the Romanians Experience the Process of Transnationalism? Canada and the UK Compared

Sociologie Românească, 2011
The rapid improvement of technologies and communication has made it easier for migrants to maintain close links with their country of origin. Given the lack of empirical investigation on transnationalism, this comparative study argues that this process ...
Claudia Paraschivescu
doaj  

EUROPEAN DIPLOMATIC ACTION IN THE CONTEXT OF NOVEL CHALLENGES RELATED TO GLOBAL CLIMATE MIGRATIONS [PDF]

EURINT, 2019
Civil wars in Darfur or Syria showed what the global effects of migration could be and proved the importance of creation of multi-stakeholder partnerships.
Monica RADU, Dorin DUSCIAC
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Boko Haram and the Geopolitics of Forced Migration in Nigeria

Journal of International Studies, 2018
Migration is currently perceived as an epitome of globalization and a measuring gauge of global geopolitical mobility. In recent years, Nigeria has been faced with a series of migratory crises such as insurgency and conflict, forcing large numbers of ...
Sadiq Mukhtar , Rosniza Aznie , Lam Kuok Choy, Amina Ummulkhair Ibrahim Bibi-Farouk   +3 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

“It spreads like wildfire”: mothers’ gatherings for vaccine acceptance

Frontiers in Public Health
This case study describes the design, implementation, and evaluation of an initiative to increase COVID-19 vaccine confidence and uptake among refugee and immigrant women in Clarkston, Georgia.
Diego de Acosta, Temple Moore, Fariha Alam, Sarah J. Hoffman, Sarah J. Hoffman, Megan Keaveney, Megan Keaveney, Erin Mann, Elizabeth Dawson-Hahn, Elizabeth Dawson-Hahn   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source