Results 51 to 60 of about 2,228,529 (317)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

To Migrate or Not to Migrate: An Analysis of Operator Migration in Distributed Stream Processing

IEEE Communications Surveys & Tutorials
One of the most important issues in data stream processing systems is to use operator migration to handle highly variable workloads in a cost-efficient manner and adapt to the needs at any given time on demand. Operator migration is a complex process that involves changes in the state and stream management of a running query, typically without any loss
Espen Volnes, Thomas Plagemann, Vera Goebel   +2 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Migration Machine

, 2011
Anyone travelling to Europe these days comes across not only barriers but also an increasing amount of technology. Bona fide travellers are offered high-tech initiatives (such as iris scans) in the hope that the desire for safety can still be combined with freedom of movement for all citizens.
Dijstelbloem, H., Meijer, A., Besters, M.   +2 more
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Migration Project in Retrospect: The Case of the Ageing Zero Generation in Emirdağ

Social Inclusion, 2018
In the twentieth century, Emirdağ (Turkey) witnessed extensive emigration and is now home to the ‘zero generation’: a group of elderly people who stayed behind when their children moved abroad.
Christiane Timmerman, Meia Walravens, Joris Michielsen, Nevriye Acar, Lore Van Praag   +4 more
doaj   +1 more source

Housing integration of immigrants from Bosnia and Herzegovina in Croatia: example of the City of Zagreb

Geoadria, 2020
This paper analyses the results of the research on housing integration as the important part of functional integration of most numerous immigrant group in Croatia – Croatian citizens who were born in Bosnia and Herzegovina. The analysed survey (CAPI) was
Sonja Podgorelec, Sanja Klempić Bogadi, Margareta Gregurović   +2 more
doaj   +1 more source