Results 31 to 40 of about 35,868 (219)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Migration Crisis, the Irregular Migrant and the Global Governance Response. Interrogating the Identity Formation Process in Programmatic Documents [PDF]

Eon
The migration crisis has become a chronic phenomenon, testing the institutional limits of the migration governance framework at the international and regional level.
Luiza-Maria FILIMON
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Communication of Public, Private and Civil Sector in Migration Crisis [PDF]

Bezbednosni Dijalozi, 2019
The migration crisis faced for the first time on a larger scale by the Republic of Croatia in the second half of the year 2015, has in fact only scratched our country and the public has been receiving information every day through radio, newspapers, and
Ivan Nađ, Ana Mirenić
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

What is crisis migration?

Forced Migration Review, 2014
Movements precipitated by humanitarian crises have implications that touch upon immigration control and national interests, human rights, humanitarian and development principles, and the frameworks for international protection, cooperation and burden ...
Susan Martin, Sanjula Weerasinghe, Abbie Taylor   +2 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

MIGRATION AND REFUGEE CRISIS: A MAJOR CHALLENGE FOR THE EUROPEAN UNION. MEASURES AND POSSIBLE SOLUTIONS IN THE CONTEXT OF YEAR 2016 [PDF]

Challenges of the Knowledge Society, 2016
The rising number of people trying to get into Europe from the Middle East and Africa has highlighted some structural problems of EU migration policy, fact which revealed the need for setting out and adoption of immediate and long-term responses to the ...
Dan VĂTĂMAN
doaj  

The Discursive Appeal to Solidarity and Partisan Journalism in Europe’s Migration Crisis

Social Inclusion, 2019
The article analyses the discursive appeal to solidarity in the mass media during the unfolding of Europe’s migration crisis. Solidarity was claimed by numerous actors in the public discourse to legitimise political decisions and mobilise public opinion.
Stefan Wallaschek
doaj   +1 more source