Results 51 to 60 of about 35,868 (219)

Zagrożenia cywilizacyjne powiązane z kryzysem migracyjnym na granicy Rzeczypospolitej Polskiej

open access: yesPoliteja
CIVILIZATION THREATS RELATED TO THE MIGRATION CRISIS ON THE BORDER OF THE REPUBLIC OF POLAND The article is devoted to the analysis of civilization threats resulting from the migration crisis on the Polish-Belarusian border.
Patryk Chmielarz
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Adolescence, food crisis and migration

open access: yesForced Migration Review, 2014
Adolescents who migrate because of food crises face distinct risks. Specific strategies are needed to prevent and respond to this phenomenon.
Janis Ridsdel
doaj  

Statelessness in the Context of the Migration Crisis in Europe: A Growing Challenge for the International Community

open access: yesCroatian Yearbook of European Law and Policy, 2020
Statelessness remains a secondary topic in the debate on the migration crisis that has been raging across Europe since 2015, but it will certainly come to the fore in the near future.
Agata Szwed
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

European Borders in Turbulent Times: The Case of the Central Mediterranean ‘Extended Borderland’

open access: yesPoliteja, 2017
This article presents one of the most salient aspects of the migration crisis in the EU, namely the turbulent management of external borders, and analyzing it in the case of the central region of the Mediterranean Sea.
Artur Gruszczak
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

New challenges for the modern migration policy of the European Union

open access: yesStudia Humanitatis, 2015
The article analyses the migration policy of the European Union in the context of contemporary global development and the existing European migration crisis. The article explains factors and principles of migration policy.
Malykha Mariia Igorivna
doaj  

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