Results 71 to 80 of about 475,391 (309)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
No. 29: Zimbabwe’s Return Migrants – Before & After Challenges [PDF]
, 2014 Various countries in the developing world have implemented policies and incentives to encourage the participation of their respective diasporas in development. The ‘best case’ countries include the Philippines, India, Mexico, Bangladesh, Nigeria, Morocco,
Mandiyanike, David
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Zagrożenia cywilizacyjne powiązane z kryzysem migracyjnym na granicy Rzeczypospolitej Polskiej
PolitejaCIVILIZATION THREATS RELATED TO THE MIGRATION CRISIS ON THE BORDER OF THE REPUBLIC OF POLAND The article is devoted to the analysis of civilization threats resulting from the migration crisis on the Polish-Belarusian border.
Patryk Chmielarz
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Adolescence, food crisis and migration
Forced Migration Review, 2014 Adolescents who migrate because of food crises face distinct risks. Specific strategies are needed to prevent and respond to this phenomenon.
Janis Ridsdel
doaj
Migration in the Context of Current Economic and Financial Crisis - Comparative Analysis [PDF]
The crisis of the global financial markets that struck the world economy in the mid 2008 affected the world economy as a whole; nevertheless, it also had a great impact upon the labour force market in the European countries.
Balan, Mariana, Uzlau, Carmen
core
Outport adaptations: Social indicators through Newfoundland\u27s Cod crisis [PDF]
, 2001 The 1992 moratorium on fishing for Northern Cod marked a symbolic end to the way of life that had sustained Newfoundland\u27s out ports for hundreds of years.
Butler, melissa J, Hamilton, Lawrence C.
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source