Results 71 to 80 of about 472,776 (289)

No. 25: Complex Movements, Confused Responses: Labour Migration in South Africa [PDF]

open access: yes, 2011
The end of apartheid undermined the rationale for apartheid-era immigration. Immigration from Europe (which had been declining in the 1980s) dwindled to almost nothing as the new government dissociated itself from the racist immigration policies of the ...
Crush, Jonathan
core   +1 more source

Turkey makes a mockery of Europe’s claim to uphold democratic values. EPC Commentary, 16 March 2016 [PDF]

open access: yes, 2014
The 7 March EU-Turkey migration crisis summit took place three days after the Turkish authorities seized Feza media group, which includes Turkey’s largest circulation daily Zaman and its English language sister paper Today’s Zaman.
Paul, Amanda
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Migration in the Context of Current Economic and Financial Crisis - Comparative Analysis [PDF]

open access: yes
The crisis of the global financial markets that struck the world economy in the mid 2008 affected the world economy as a whole; nevertheless, it also had a great impact upon the labour force market in the European countries.
Balan, Mariana, Uzlau, Carmen
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Zagrożenia cywilizacyjne powiązane z kryzysem migracyjnym na granicy Rzeczypospolitej Polskiej

open access: yesPoliteja
CIVILIZATION THREATS RELATED TO THE MIGRATION CRISIS ON THE BORDER OF THE REPUBLIC OF POLAND The article is devoted to the analysis of civilization threats resulting from the migration crisis on the Polish-Belarusian border.
Patryk Chmielarz
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Institutional Reactions to the Impact of Global Crisis at Source and Destination Cities of Migration in China [PDF]

open access: yes
This paper relates on the impact of global crisis on China from a systemic point of view. In what ways external and internal adaptation pressures influenced the transformation of the party-state system in China?
Maria Csanadi
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Cyclical Dimensions of Labour Mobility after EU Enlargement [PDF]

open access: yes
This paper explores the influence of the economic cycle on labour mobility within the EU, focusing on the likely impact of the present economic crisis. To do so, we use an econometrically calibrated simulation and a case study of Ireland.
Alan Ahearne   +3 more
core   +3 more sources

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