Results 81 to 90 of about 695,851 (315)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Studying social transformation and international migration

, 2010
Castles S. Studying social transformation and international migration. COMCAD Arbeitspapiere - working papers, 83. Bielefeld: COMCAD - Center on Migration, Citizenship and Development; 2010.This paper examines the methodological dilemmas that arise at ...
Castles, Stephen
core  

Influence of the antiseptic octenidine on spectral characteristics and energy migration processes in photosystem II core complexes. [PDF]

Photosynth Res, 2023
Paschenko VZ, Lukashev EP, Mamedov MD, Korvatovskiy BN, Knox PP.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

THE CHEMICAL COMPOSITION OF SURFACE WATERS OF THE BASIN OF THE OKA RIVER IN THE TERRITORY OF THE ORYOL REGION

RUDN Journal of Ecology and Life Safety, 2015
One of the main environmental problems of the industrial cities consists in intensive pollution of a surface water harmful substances. Studying of the ecological environment of the city is based on use of both traditional, and modern methods of research ...
L P Stepanova, E V Yakovleva, E S Chernyi, A V Pisarev   +3 more
doaj  

The role of migration processes and cultural factors in the classification of personality disorders. [PDF]

Transcult Psychiatry, 2023
Najjarkakhaki A, Ghane S.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The determinants of international migration: conceptualizing policy, origin and destination effects: DEMIG project paper no. 2

, 2011
The effectiveness of migration policies has been widely contested in the face of their supposed failure to steer immigration and their hypothesized unintended, counter-productive effects.
de Haas, Hein
core  

THE IMPACT OF CAUCASIAN WAR ON INTERNAL MIGRATION OF THE POPULATION OF DAGESTAN

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2018
The Caucasian war had a significant impact on both the internal and the external migration situation in Dagestan. First noticeable negative impact made war on internal seasonal movement of highlanders to the plains to exchange goods, livestock and ...
D. U. Akhmedova, K. V. Gadzhieva
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source