Results 71 to 80 of about 325,848 (294)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Introduction to the Special Issue “Arts and Refugees: Multidisciplinary Perspectives”

Arts, 2019
Even though the percentage of migrants and refugees in the world has remained relatively stable over the past few decades, in recent years, public debate on this matter has become increasingly sensitive and politicized [...]
Marco Martiniello
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Modeling Credit Risk by Affine Processes [PDF]

In this paper, the treasury rates and the credit migrations are jointly modeled by multi-dimensional affine processes. In order to capture the entire information, including credit migrations and default events, we construct non-conservative regular ...
Damir Filipovic, Li Chen
core  

Iron Age and Anglo-Saxon genomes from East England reveal British migration history [PDF]

, 2016
British population history has been shaped by a series of immigrations, including the early Anglo-Saxon migrations after 400 CE. It remains an open question how these events affected the genetic composition of the current British population.
A Sajantila, AL Topf, AW Briggs, B Winney, C Capelli, CT O'Dushlaine, D Petts, G Jun, GB Busby, H Eckardt, H Härke, H Jònsson, H Li, H Li, HX Zheng, I Lazaridis, J Hines, J Montgomery, J Novembre, JK Pickrell, M Meyer, M Schubert, ME Weale, MG Thomas, N Patterson, N Rohland, P Balaresque, P Brotherton, P Budd, P Ralph, P Skoglund, PR Staab, S Besenbacher, S Leslie, S Schiffels, T Sundell, W Haak, Wellcome Trust   +37 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

De la lutte pour vivre au combat politique : sur les traces des origines de la lutte des biffins

Lien Social et Politiques, 2014
Au début des années 2000, au marché de la porte Montmartre à Paris, certains de ses vendeurs d’objets de seconde main, récupérés le plus souvent dans les poubelles de la capitale, se montent en association pour s’opposer aux descentes de police dont ils ...
Mélanie Duclos
doaj   +1 more source

Crossover Behaviour of 3-Species Systems with Mutations or Migrations

, 2004
We study the ABC model in the cyclic competition and neutral drift versions, with mutations and migrations introduced into the model. When stochastic phenomena are taken into account, there are three distinct regimes in the model.
Bergersen, Birger, Ifti, Margarita
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Sous-traitance et bureaucratisation néolibérale : une analyse de l’interface de la distance dans l’accueil des demandeurs d’asile

Lien Social et Politiques, 2019
En mettant à l’épreuve de l’ethnographie les questions posées par la sous-traitance, cet article s’intéresse à la bureaucratisation néolibérale de l’accueil des demandeurs d’asile en Suisse.
Camilla Alberti
doaj   +1 more source