Results 51 to 60 of about 772,602 (293)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Application of Numerical Modeling and GIS for Simulating Inundation Under Dam Failure Scenarios

Civil and Environmental Engineering
Dam failure and unsafe dam reservoirs cause extremely serious flooding and affecting the environment and ecosystem in the downstream area. The study applied numerical modelling (MIKE 11, MIKE 21, MIKE FLOOD) combined with GIS technology to simulate ...
Hanh Dong Kim, Truong Dinh Duc, Bui Kien-Trinh Thi   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Assessment of flood mitigation services in Khon Kaen City through integrated modelling and scenario simulations

Engineering and Applied Science Research, 2023
This study highlighted the identifying remedial measures for flood mitigation under varying rainfall intensity. The MIKE URBAN was coupled with the MIKE 21 within the MIKE FLOOD URBAN model to simulate flood propagation in Khon Kaen City. The reliability
Wanwipha Pantusoknaporn, Fatah Masthawee, Supapap Patsinghasanee, Kittiwet Kuntiyawichai   +3 more
doaj  

Mike 21 Model Based Numerical Simulation of the Operation Optimization Scheme of Sedimentation Basin

Coatings, 2022
The sedimentation basin is an important part of hydraulic engineering. Because the prototype size is too large and not easy to analyze, Mike 21 has the advantages of easy input, conversion, analysis, and demonstration of data results, which are flexible and convenient; however, this method has not been used in hydraulic engineering by previous ...
Jun Yan, Meng Chen, Linjuan Xu, Qingyan Liu, Hongling Shi, Na He   +5 more
openaire   +1 more source

Analysis Of Erosion And Sedimentation Patterns Using Software Of Mike 21 Hdfm-mt In The Kapuas Murung River Mouth Central Kalimantan Province [PDF]

, 2012
The public transportation system along the Kapuas River, Central Kalimantan are highly depend on water transportation. Natural condition gives high distribution to the smoothness of the vessel traffic along the Kapuas Murung River.
Novico, F. (Franto), Priohandono, Y. A. (Yusuf)   +1 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Numerical model in water quality: The case study of Da Nang City in central Vietnam

River
The planning and treatment of wastewater discharged into rivers and seas is vital for tourism, domestic water supply, and other key sectors. This study used the MIKE 21 model to evaluate water quality trends and the assimilative capacity of the Vu Gia ...
Doan Thuy Kim Phuong, Vo Ngoc Duong, Nguyen Trung Quan, Nguyen Cong Phong, Doan Thi Ngoc Canh   +4 more
doaj   +1 more source

Study of the Effect of an Environmentally Friendly Flood Risk Reduction Approach on the Oman Coastlines during the Gonu Tropical Cyclone (Case Study: The Coastline of Sur)

Eng, 2021
Tropical cyclones may be destructive in the coastal region, such as the Gonu tropical cyclone, which affected the Arabian Peninsula and parts of southern Iran in 2007.
Masoud Banan-Dallalian, Mehrdad Shokatian-Beiragh, Aliasghar Golshani, Alireza Mojtahedi, Mohammad Ali Lotfollahi-Yaghin, Shatirah Akib   +5 more
doaj   +1 more source