Results 161 to 170 of about 828,815 (378)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

Identifying the earliest sign of pathological cognitive decline by using magnetic resonance imaging structural brain connectivity analysis [PDF]

open access: yes, 2017
PosterINTRODUCTION: With the increasing understanding of subjective cognitive decline (SCD) as a possible precursor of mild cognitive impairment (MCI) and Alzheimer’s disease (AD), the early identification of those with truly pathological SCD, and ...
Hui, ESK, Kwan, JSK, Mak, HKF, Xu, X
core  

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang   +6 more
wiley   +1 more source

O3‐06‐05: MULTIPLE MEMORY TESTS SUBSTANTIALLY IMPROVE LONGITUDINAL PREDICTION OF PROGRESSION TO MILD COGNITIVE IMPAIRMENT [PDF]

open access: bronze, 2019
Daniel E. Gustavson   +8 more
openalex   +1 more source

Mild cognitive impairment as a diagnostic entity

open access: yesJournal of Internal Medicine, 2004
R. Petersen
semanticscholar   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari   +3 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

Electroencephalography-based classification of Alzheimer’s disease spectrum during computer-based cognitive testing

open access: yesScientific Reports
Alzheimer’s disease (AD) is a progressive disease leading to cognitive decline, and to prevent it, researchers seek to diagnose mild cognitive impairment (MCI) early.
Seul-Kee Kim   +4 more
doaj   +1 more source

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