Results 191 to 200 of about 792,865 (388)
Practice guideline update summary: Mild cognitive impairment
Neurology, 2018 R. Petersen +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee +13 more
wiley +1 more source
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study [PDF]
, 2004 Tiia Anttila +9 more
openalex +1 more source
Mild cognitive impairment: a concept in evolution
Journal of Internal Medicine, 2014 R. Petersen +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis
Advanced Science, EarlyView.This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu +9 more
wiley +1 more source
Preserving Cognition in Older African Americans with Mild Cognitive Impairment. [PDF]
, 2016 Casten, Robin J, Rovner, Barry W
core +2 more sources
Modeling Big Medical Survival Data Using Decision Tree Analysis with Apache Spark [PDF]
, 2019 In many medical studies, an outcome of interest is not only whether an event occurred, but when an event occurred; and an example of this is Alzheimer’s disease (AD).
Abdelqader, Ikhlas +4 more
core +1 more source
Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation
Advanced Science, EarlyView.AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang +7 more
wiley +1 more source
Medial temporal lobe function and structure in mild cognitive impairment [PDF]
, 2004 Bradford C. Dickerson +10 more
openalex +1 more source