Results 41 to 50 of about 307,888 (268)

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Fully nonlocal stochastic control problems with fractional Brownian motions and Poisson jumps

AIMS Mathematics, 2021
In this paper, we establish a representation of mild solutions to fully nonlocal stochastic evolution problems. Through the iterative technique and energy estimates, we obtain the existence and uniqueness of mild solution.
Yongqiang Fu, Lixu Yan
doaj   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Heat equation with general stochastic measure colored in time

Modern Stochastics: Theory and Applications, 2014
A stochastic heat equation on $[0,T]\times \mathbb{R}$ driven by a general stochastic measure $d\mu (t)$ is investigated in this paper. For the integrator μ, we assume the σ-additivity in probability only. The existence, uniqueness, and Hölder regularity
Vadym Radchenko
doaj   +1 more source

Averaging principle for the one-dimensional parabolic equation driven by stochastic measure

Modern Stochastics: Theory and Applications, 2022
A stochastic parabolic equation on $[0,T]\times \mathbb{R}$ driven by a general stochastic measure is considered. The averaging principle for the equation is established. The convergence rate is compared with other results on related topics.
Boris Manikin
doaj   +1 more source

Existence and Uniqueness of Mild Solution for Fractional Integrodifferential Equations [PDF]

Advances in Difference Equations, 2010
We study the existence and uniqueness of mild solution of a class of nonlinear fractional integrodifferential equations dqu(t)/dtq+Au(t)=f(t,u(t))+∫0ta(t−s)g(s,u(s))ds, t∈[0,T], u(0)=u0, in a Banach space X, where 0<q<1. New results are obtained by fixed point theorem.
Fang Li, Gaston M. N’Guérékata
openaire   +3 more sources

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Mild solutions of semilinear elliptic equations in Hilbert spaces

Journal of Differential Equations, 2017
This paper extends the theory of regular solutions ($C^1$ in a suitable sense) for a class of semilinear elliptic equations in Hilbert spaces. The notion of regularity is based on the concept of $G$-derivative, which is introduced and discussed. A result of existence and uniqueness of solutions is stated and proved under the assumption that the ...
Federico, Salvatore, Gozzi, Fausto
openaire   +5 more sources

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

Second order evolutionary partial differential variational-like inequalities

AIMS Mathematics, 2022
This work is dedicated to the study of a second order evolutionary partial differential variational-like inequality in Banach space. We obtain the mild solution of our problem by applying the concept of strongly continuous cosine family of bounded linear
Imran Ali, Faizan Ahmad Khan, Haider Abbas Rizvi, Rais Ahmad, Arvind Kumar Rajpoot   +4 more
doaj   +1 more source