Results 61 to 70 of about 5,028,361 (312)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Existence, Uniqueness and stability of Mild Solution of Lipschitzian Quantum Stochastic Differential Equations [PDF]
, 2015 We introduce the concept of a mild solution of Lipschitzian quan-tum stochastic di_erential equations (QSDEs). Results on existence, uniqueness and stability of mild solution of QSDEs are established.
Agarana, M. C. +4 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Mild Solutions for Fractional Differential Equations with Nonlocal Conditions [PDF]
Advances in Difference Equations, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2007 Mesoporous silicas with various morphologies and structures were synthesized with the aid of 2,2,4-trimethylpentane (TMP) in the presence of nonionic surfactant P123 [(EO)(20)(PO)(70)(EO)(20)] as a structure-directing agent under mild reaction conditions
Li, Congming +5 more
core +1 more source
An analytic solution to the mild slope equation for waves propagating over an axi-symmetric pit [PDF]
, 2007 An analytic solution to the mild slope equation is derived for waves propagating over an axi-symmetric pit located in an otherwise constant depth region.
Jung, Tae-Hwa, Suh, Kyung-Duck
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Controllability of Mild Solution of Nonlocal Conformable Fractional Differential Equations
, 2022 In many research works Bouaouid et al. have proved the existence of mild solutions of an abstract class of nonlocal conformable fractional Cauchy problem of the form: dαxt/dtα=Axt+ft,xt,x0=x0+gx,t∈0,τ.
Mohamed Bouaouid +2 more
core +1 more source