Results 61 to 70 of about 4,403,877 (318)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Social Competence and Executive Functioning in Adolescents Following a Mild Traumatic Brain Injury [PDF]
, 2014 A traumatic brain injury (TBI) is one of the most common injuries sustained by adolescents and a leading cause of death and long-term disability. The vast majority of these cases are mild and yet they can cause a range of difficulties across multiple ...
Hollands, David Michael
core
Controllability of Mild Solution of Nonlocal Conformable Fractional Differential Equations
, 2022 In many research works Bouaouid et al. have proved the existence of mild solutions of an abstract class of nonlocal conformable fractional Cauchy problem of the form: dαxt/dtα=Axt+ft,xt,x0=x0+gx,t∈0,τ.
Mohamed Bouaouid +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Existence of mild solutions for fractional neutral evolution equations
Computers & Mathematics with Applications, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Yong Zhou, Feng Jiao
openaire +3 more sources
, 2007 Dechlorination of octachlorodibenzo-p-dioxin (OCDD) was carried out in ethanol-water (v/v = 1:1) solution of NaOH in the presence of Pd/C catalysts with the use of H-2. The substrate was dechlorinated with Pd/C under mild conditions (atmospheric pressure
Chen, Jiping +5 more
core +1 more source
Living in Sandwell: An Exploratory Study into the Key Issues and Challenges that Affect a Small Group of People with Mild Learning Disabilities [PDF]
, 2008 This paper is concerned with a small group of people with a mild learning disability; who they are and what their lives are like. This group is not typically known by the label of mild learning disability in research, social policy or in service ...
Tilly, Liz
core +2 more sources
, 2023 So, read this article for more information about Candida Diet Solution Formula is a complete ...
Candida Diet Solution
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source