Results 81 to 90 of about 1,107,444 (285)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Neutral functional differential equations of second-order with infinite delays

Electronic Journal of Differential Equations, 2010
This work shows the existence of mild solutions to neutral functional differential equations of second-order with infinite delay. The Hausdorff measure of noncompactness and fixed point theorem are used, without assuming compactness on the associated
Runping Ye, Guowei Zhang
doaj  

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Almost Periodicity of Mild Solutions of Inhomogeneous Periodic Cauchy Problems

Journal of Differential Equations, 1999
The authors consider a mild solution \(u\) to the well-posed inhomogeneous Cauchy problem \[ u'(t)= A(t)u(t)+ f(t), \] on a Banach space \(X\), where \(A(\cdot)\) is periodic. For a problem on \(\mathbb{R}_+\) the authors show that \(u\) is asymptotically almost-periodic if \(f\) is asymptotically almost-periodic, \(u\) is bounded, uniformly continuous
Batty, C, Hutter, W, Rabiger, F
openaire   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Global Existence and Stability for Neutral Functional Evolution Equations with State-Dependent Delay

Nonautonomous Dynamical Systems, 2014
In this paper we prove the global existence and attractivity of mild solutions for neutral semilinear evolution equations with state-dependent delay in a Banach space.
Baliki Abdessalam, Benchohra Mouffak
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Approximations of solutions to nonlinear Sobolev type evolution equations

Electronic Journal of Differential Equations, 2003
In the present work we study the approximations of solutions to a class of nonlinear Sobolev type evolution equations in a Hilbert space. These equations arise in the analysis of the partial neutral functional differential equations with unbounded delay.
Dhirendra Bahuguna, Reeta Shukla
doaj  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source