Results 81 to 90 of about 4,403,877 (318)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Mesoporous titanosilicates with high loading of titanium synthesized in mild acidic buffer solution

, 2009
Mesoporous titanosilicates with high titanium content were synthesized under mild acidic conditions (pH = 4.4, HAc-NaAc buffer solution) by co-condensation of acetylacetone-modified titanium isopropoxide (Ti(OBu '')(3) (acac)) and mixture of sodium ...
Yang, J., Fan, F., Tang, Jianting, Liu, Jian, Yang, Q., Yang, Jie, 杨启华, Tang, J., Feng, Zhaochi, Feng, Z., Fan, Fengtao, Yang, Qihua   +11 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Controllability of Mild Solution to Hilfer Fuzzy Fractional Differential Inclusion with Infinite Continuous Delay

Fractal and Fractional
This work investigates the solvability of the generalized Hilfer fractional inclusion associated with the solution set of a controlled system of minty type–fuzzy mixed quasi-hemivariational inequality (FMQHI).
Aeshah Abdullah Muhammad Al-Dosari
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Corrosion Inhibition of Polydopamine Nanoparticles on Mild Steel in Hydrochloric Acid Solution

, 2017
The spherical polydopamine (PDA) nanoparticles with a uniform particle size around 230nm were synthesized successfully by self-polymerization of dopamine hydrochloride in Tris-buffer solution. The inhibitor effects of PDA nanopartilces on mild steel in 1
Zheng, Wenru, Zhao, Haichao, Wang, Liping, Liu, Tong, Dai, Zhendong, Li, Xiangyu, Yang, Feng   +6 more
core  

Influence of reaction conditions on the properties of solution-processed Cu2ZnSnS4 nanocrystals [PDF]

, 2014
Cu2ZnSnS4 nanocrystals were fabricated by hot injection of sulphur into a solution of metallic precursors. By careful control of the reaction conditions it was possible to control the elemental composition of the nanocrystals such that they are suitable ...
Qu, Yongtao, Zoppi, Guillaume, Beattie, Neil, Miles, Robert   +3 more
core   +1 more source

Mild-Temperature Photothermal Effect Enhanced by Functional Conjugated Polymer Nanoparticles through Enzyme-Mediated Starvation

, 2022
Mild-temperature photothermal therapy (PTT) is being extensively explored because it causes less injury to normal cells. However, the effect of mild-temperature PTT is decreased because of heat shock protein (HSP) overexpression.
Chengfen Xing, Mengying Li, Junjie Qi, Junjie Qi (1567870), Mei Zhou, Dong Gao, Ning Li (45258), Chengfen Xing (1567876), Mei Zhou (269746), Dong Gao (372551), Mengying Li (410153), Ning Li, Xiao Wei, Xiao Wei (44054)   +13 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Neutral functional differential equations of second-order with infinite delays

Electronic Journal of Differential Equations, 2010
This work shows the existence of mild solutions to neutral functional differential equations of second-order with infinite delay. The Hausdorff measure of noncompactness and fixed point theorem are used, without assuming compactness on the associated
Runping Ye, Guowei Zhang
doaj