Results 51 to 60 of about 1,036,048 (312)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Second order evolutionary partial differential variational-like inequalities

AIMS Mathematics, 2022
This work is dedicated to the study of a second order evolutionary partial differential variational-like inequality in Banach space. We obtain the mild solution of our problem by applying the concept of strongly continuous cosine family of bounded linear
Imran Ali, Faizan Ahmad Khan, Haider Abbas Rizvi, Rais Ahmad, Arvind Kumar Rajpoot   +4 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Stochastic differential equation involving Wiener process and fractional Brownian motion with Hurst index $H> 1/2$

, 2011
We consider a mixed stochastic differential equation driven by possibly dependent fractional Brownian motion and Brownian motion.
Garsia A. M., Georgiy M. Shevchenko, Kleptsyna M., Kubilius K., Nualart D., Samko S., Yulia S. Mishura   +6 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Existence of mild solutions for quasilinear integrodifferential equations with impulsive conditions

Electronic Journal of Differential Equations, 2009
We prove the existence and uniqueness of mild solutions of quasilinear integrodifferential equations with nonlocal and impulsive conditions in Banach spaces. The results are obtained by using a fixed point technique and semigroup theory. Examples are
Krishnan Balachandran, Francis Paul Samuel   +1 more
doaj  

Renormalized solutions of semilinear equations involving measure data and operator corresponding to Dirichlet form

, 2015
We generalize the notion of renormalized solution to semilinear elliptic and parabolic equations involving operator associated with general (possibly nonlocal) regular Dirichlet form and smooth measure on the right-hand side.
Klimsiak, Tomasz, Rozkosz, Andrzej
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Boundary controllability of impulsive nonlinear fractional delay integro-differential system

Cogent Engineering, 2016
By using the strongly continuous semigroup theory and the Banach contraction principle, we study the boundary controllability of time varying delay impulsive nonlinear fractional integrodifferential system in Banach spaces.
Hamdy M. Ahmed
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source