Results 71 to 80 of about 81,349 (289)

Neuropsychiatric aspects of concussion: acute and chronic sequelae

Concussion, 2017
Concussion – also known as mild traumatic brain injury – is a transient disturbance of neurological function resulting from traumatic forces imparted to the brain that often produce cognitive, beha...
Vani Rao, Arshiya Syeda, Durga Roy, Matthew E Peters, Sandeep Vaishnavi   +4 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Neuroprotective effects of cold-inducible RNA-binding protein during mild hypothermia on traumatic brain injury

Neural Regeneration Research, 2016
Cold-inducible RNA-binding protein (CIRP), a key regulatory protein, could be facilitated by mild hypothermia in the brain, heart and liver. This study observed the effects of mild hypothermia at 31 ± 0.5°C on traumatic brain injury in rats.
Guan Wang, Jian-ning Zhang, Jia-kui Guo, Ying Cai, Hong-sheng Sun, Kun Dong, Cheng-gang Wu   +6 more
doaj   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

A Modern Approach to the Treatment of Traumatic Brain Injury

Medicines
Background: Traumatic brain injury manifests itself in various forms, ranging from mild impairment of consciousness to severe coma and death. Traumatic brain injury remains one of the leading causes of morbidity and mortality.
Marat Syzdykbayev, Maksut Kazymov, Marat Aubakirov, Aigul Kurmangazina, Ernar Kairkhanov, Rustem Kazangapov, Zhanna Bryzhakhina, Saule Imangazinova, Anton Sheinin   +8 more
doaj   +1 more source

Autonomic Dysfunction after Mild Traumatic Brain Injury

Brain Sciences, 2017
A mild traumatic brain injury (mTBI) is a complex pathophysiologic process that has a systemic effect on the body aside from solely an impairment in cognitive function.
Dmitry Esterov, Brian D. Greenwald
doaj   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Towards the Development of an Integrative, Evidence-Based Suite of Indicators for the Prediction of Outcome Following Mild Traumatic Brain Injury: Results from a Pilot Study [PDF]

, 2020
Aleksandra Gozt, Melissa K. Licari, Alison Halstrom, Hannah Milbourn, Stephen Lydiard, Anna M. B. Black, Glenn Arendts, Stephen Macdonald, Swithin Song, Ellen MacDonald, Philip Vlaskovsky, Sally Burrows, Michael Bynevelt, Carmela Pestell, Daniel M Fatovich, Melinda Fitzgerald   +15 more
openalex   +1 more source