Results 141 to 150 of about 2,518,262 (366)

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

open access: yesAdvanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai   +5 more
wiley   +1 more source

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

open access: yesAdvanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long   +17 more
wiley   +1 more source

Taking Care of Our Own: Lessons Learned About Engaging Military Families in Youth Mentoring [PDF]

open access: yes, 2014
This report offers valuable findings from the Amachi Expansion for Military and Civilian Families (AEMCF) project, one of the first large-scale efforts to provide mentoring to military-connected children across multiple states.
Antoinette Basualdo-Delmonico   +1 more
core  

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

open access: yesAdvanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu   +10 more
wiley   +1 more source

Women in the Sphere of Masculinity: The Double-Edged Sword of Women’s Integration in the Military [PDF]

open access: yes, 2007
Too many women together are not a good thing anywhere, especially not in the military.2 Noa is one of numerous women who have managed to cross traditional gender lines in the Israeli military in the last decade, assigned to positions that typically had ...
Rimalt, Noya
core   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen   +9 more
wiley   +1 more source

THE MILITARY METEOROLOGICAL SERVICE IN THE UNITED STATES DURING THE WAR

open access: hybrid, 1919
BERTRAM J. SHERRY, Alan T. Waterman
openalex   +1 more source

Eighteenth-century theatrical war plays and the experience of war [PDF]

open access: yes, 2012
In my paper I will discuss ‘war plays’ as they were presented on the 18th-century stage in relation to the question how the identification of the audience with ‘the military’ was realized or prohibited by means of theatricality.
van der Haven, Kornee
core   +1 more source

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