Results 61 to 70 of about 405,640 (313)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

EWOLUCJA PRAWA OCHRONY GRANIC POLSKI W XX-XXI WIEKU

Zeszyty Prawnicze, 2016
THE EVOLUTION OF POLISH BORDER PROTECTION LAW IN 20TH AND 21ST CENTURY Summary The borderland, i.e. the area of land close to the border between two countries, is always a piece of land of exceptional importance. Depending on the current situation the
Lech Grochowski
doaj   +1 more source

DIPLOMACY AND DEFENSE SPATIAL PLANNING

Dinamika Global, 2020
The border issue is one of the important aspects related to the main elements for the establishment of a state. From a defense point of view, the unclear physical and juridical boundaries of the territory will make it even more difficult to carry out ...
Renaldo Benarrivo, Nala Nourma Nastiti
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

SINO-INDIAN MILITARY AND BORDER DISPUTES INCLUDING THE 1962 WAR: IMPLICATIONS AND LESSONS FOR PAKISTAN

Margalla Papers
The study aims to explore China-India disputes, their implications and lessons for Pakistan. Since 1960, China and India have border disputes that have led to several clashes.
Sheraz Baig, Syed Umad Ul Hassan , Habib Ullah Khan Afridi   +2 more
doaj   +3 more sources

EFFECT OF ENDURANCE EXERCISE ON BRAIN NATRIURETIC PEPTIDE (BNP)

Khyber Medical University Journal, 2013
OBJECTIVE: To evaluate the effect of maximal exercise on the level ofbrain natriuretic peptide (BNP) and cardiac adaptive changes in endurancetrained elite athletes and sedentary healthy subjects.
Hafeezullah Wazir Ali, Muhammad Aslam, Sohail Aziz, Muhammad Mazhar Hussain, Farmanullah Wazir   +4 more
doaj  

Twenty years of Poland–Ukraine cross-border cooperation: reflections and responses in the wake of the Russian military aggression

Space, Society, Economy
This paper marks the 20th anniversary of Poland–Ukraine cross-border cooperation (CBC), emphasising the impacts of the recent Russian military aggression.
Dmitrij Wolodin, Katarzyna Wyporska
doaj   +1 more source

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source

MOBILIZATION TRAINING AS A FACTOR IN ROAD CONSTRUCTION IN THE USSR IN THE 1920S

Sovremennye Issledovaniâ Socialʹnyh Problem, 2020
Purpose. The article is devoted to the study of the history of the construction of strategic roads in the Western border strip of the USSR in the context of Soviet mobilization training in the 1920s.
Oksana Yurevna Repukhova
doaj   +1 more source