Results 71 to 80 of about 405,640 (313)
Advanced Science, EarlyView.This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu +20 more
wiley +1 more source
The ISCIP Analyst, Volume IX, Issue 11 [PDF]
, 2004 This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and ...
Adami, Fabian +6 more
core
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
INFORMATION INFLUENCE ON UKRAINIAN SOCIETY PUBLIC OPINION
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2016 Currently the Russian Federation is carrying out open military aggression against Ukraine using various means of forming public opinion in different regions in order to destabilize socio-political and economic situation in the country.
Nataliia M. Voloshyna +1 more
doaj
THE MILITARY ENGINEER STRUCTURES IN COUNTERACTING HYBRID THREATS
Bulletin of "Carol I" National Defense University, 2021 The military engineer structures, both in NATO and in the Romanian Army, have played a historical and critical role in shaping the operational environment.
Andrei Th. CONSTANTIN
doaj
Legitimating violence: military operations within Brazilian borders
, 2022 The distinction between armed forces and police is traditionally addressed through the division between the domestic and international realms, which equates three different and independent kinds of boundaries: physical borders, the reach of political authority, and the belonging to a community.
openaire +1 more source
"Fifty-four Forty or Fight!" [PDF]
This paper develops an explanation for historical differences in the ways in which territorial disputes between sovereign states have been resolved. The main innovation in the analysis is to allow for three possible equilibria: ú an unfortified border; ú
Herschel I. Grossman
core
Advanced Science, EarlyView.The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu +9 more
wiley +1 more source
Shaheen & Hassan Popular in State; Pappas Most Well-Known Candidate to Replace Shea-Porter 4/26/18 [PDF]
, 2018 Senator Jeanne Shaheen continues to be the most popular member of the state\u27s congressional delegation, closely followed by her colleague Senator Maggie Hassan.
Survey Center, UNH
core +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source