Results 31 to 40 of about 674,181 (255)
Advanced Science, EarlyView.The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu +11 more
wiley +1 more source
Deprivation, Despoilation And Destitution: Whither Environment And Human Rights In Nigeria\u27s Niger Delta? [PDF]
, 2001 Upon the inception of the new civilian administration on May 29\u27 2000, after almost twenty years of military rule, President Olusegun Obasanjo set up, inter alia, an eight-member Human Rights violation Investigation ...
Worika, Ibibia Lucky
core +1 more source
Logistics and the Chaco War Bolivia versus Paraguay, 1932-1935 [PDF]
, 2005 This article provides an assessment of how Paraguay, the weaker power, managed to defeat Bolivia in the 1932-35 Chaco War, fought over the disputed and remote Gran Chaco region that separated the two countries.
Hughes, M
core +1 more source
Advanced Science, EarlyView.A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng +13 more
wiley +1 more source
The EU as a security actor in Africa [PDF]
, 2015 Instability and conflict in Africa create a range of security problems for Europe. Rapidly increasing migration via the Mediterranean Sea, extremism and terrorism, as well as cross-border crime, all have implications for security in Europe, but are spill-
Hoebeke, Hans +3 more
core
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Advanced Science, EarlyView.A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng +5 more
wiley +1 more source
Crerar and the Decision to Garrison Hong Kong [PDF]
, 2012 Acrimonious and often virulent debate surrounds examinations of the Canadian expeditionary force dispatched to Hong Kong in the fall of 1941. The tragic fate of the Royal Rifles of Canada and the Winnipeg Grenadiers in the battle for Hong Kong and their ...
Dickson, Paul
core +1 more source