Results 71 to 80 of about 1,923,883 (334)

Traumatisme culturel et victimes de la dictature sous le gouvernement Bolsonaro

Brésil(s)
The article focuses on Brazil’s Amnesty Commission, the body responsible for compensating the victims of the military dictatorship. Our aim is to understand what we call deconstruction of trauma, which requires the mobilization of moral and political ...
Matheus Vitorino, Barbara Goulart
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

The Marianas Covenant Negotiations [PDF]

, 1980
In September 1969, the United States and the Congress of Micronesia\u27s Joint Committee on Future Status began their negotiations. This article will examine the negotiations which commenced in December 1972 and will concentrate on the three areas which ...
Liebowitz, Arnold H.
core   +2 more sources

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Anti-peasant activities of the All-Russian Extraordinary Commission for Combating Counter-Revolution, Speculation, and Sabotage organs in the Volga Region and in the Ural Region during the Civil War

Вестник Самарского университета: История, педагогика, филология, 2020
The article focuses on the anti-peasant activities of the All-Russian Extraordinary Commission for Combating Counter-Revolution, Speculation, and Sabotage organs in the Volga Region and in the Ural Region during the Civil War.
P. A. Mistryugov
doaj   +1 more source

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

Advanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen, Wei Zeng, Zherui Zhao, JiYu Zhao, Ziyan Huang, Zhuo Chen, Kui Zhou, Guanglong Ding, Su‐Ting Han, Ye Zhou   +9 more
wiley   +1 more source

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

Advanced Science, EarlyView.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang, Wen Sun, Ting Xiao, Yali Wang, Xianlan Wu, Huiyou Chen, Ming Chen, Jun Zhang   +7 more
wiley   +1 more source

PUBLIC-PRIVATE PARTNERSHIP AT THE MILITARY-INDUSTRIAL COMPLEX

RUDN Journal of Public Administration, 2014
The article deals with the current issues of effective development of public-private partnership at the military-industrial complex of Russia.
Maxim Yu Glybin
doaj  

Truth no more? The Struggle over the National Truth Commission in Brazil

Iberoamericana. América Latina - España - Portugal, 2014
The Plan called Third National Programme of Human Rights, or PNDH-3, created by the Federal Minister Paulo Vannuchi, exmilitant of a terrorist group, is key proposal is to create a National Truth Commission (NCT) to investigate human rights violations ...
Nina Schneider
doaj   +1 more source