Results 31 to 40 of about 555,665 (313)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

China’s Defense Cooperation with Latin America and Caribbean: Trends and Limitations

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. China started to develop military-to-military ties and defense-industrial cooperation with Latin America and Caribbean countries in the early 2000s as an element of its strategy of comprehensive cooperation with the region. Defense
Vasily Kashin, Ekaterina Kosevich
doaj   +1 more source

Beyond Fashoda: Anglo-French security cooperation in Africa since St-Malo [PDF]

, 2010
Traditionally divided on security matters, France and Britain broke new ground when they signed the 1998 Saint-Malo agreement, promising to collaborate on defence and security, and pledging to cooperate bilaterally and in a ‘bi-multi’ fashion on Africa ...
Chafer, Tony, Cumming, G.
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling

Cell Death and Disease
CD146 plays a key role in cancer progression and metastasis. Cancer stem cells (CSCs) are responsible for tumor initiation, drug resistance, metastasis, and recurrence. In this study, we explored the role of CD146 in the regulation of liver CSCs.
Bing Yan, QiuYu Lu, TianMing Gao, KunQing Xiao, QianNi Zong, HongWei Lv, GuiShuai Lv, Liang Wang, ChunYing Liu, Wen Yang, GuoQing Jiang   +10 more
doaj   +1 more source

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

Advanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen, Wei Zeng, Zherui Zhao, JiYu Zhao, Ziyan Huang, Zhuo Chen, Kui Zhou, Guanglong Ding, Su‐Ting Han, Ye Zhou   +9 more
wiley   +1 more source

Multifunctional Eutectic Mixtures Enable Integrated Recovery of U, Pu, and Sr From Nuclear Waste

Advanced Science, EarlyView.
A novel class of multifunctional eutectic mixtures, crafted from crown ether and organophosphorus molecules, achieves highly efficient, simultaneous recovery of uranium, plutonium, and strontium from nuclear waste. The material operates via a dual “coordination‐encapsulation” mechanism within self‐assembled reverse‐micelle structures, offering a ...
Yifan Wang, Yanjun Lv, Qilong Tang, Huaixin Hao, Jianfeng Jia, Gang Ye, Jing Chen, Chao Xu, Zhipeng Wang   +8 more
wiley   +1 more source

“I’d Rather Be in Afghanistan”: Antinomies of \u3cem\u3eBattle: Los Angeles\u3c/em\u3e [PDF]

, 2014
This article reads Battle: Los Angeles (2011) against the grain to argue that the film possesses an antiwar undertow running unexpectedly counter to its surface-level pro-military politics. The article uses the antinomy structuring Battle: Los Angeles as
Canavan, Gerry
core   +1 more source

Zero Thermal Expansion and Local Structure in KxMnxFe2‐xMo3O12‐Based Materials

Advanced Science, EarlyView.
Local structure engineering via ion insertion drives local structural transformation from low‐symmetry P21/a to high‐symmetry R‐3c, enhancing structural flexibility and realizing a transition from positive thermal expansion to wide‐temperature‐range zero thermal expansion in KxMnxFe2‐xMo3O12‐based materials.
Gongsen He, Yongqiang Qiao, Shibo Zhao, Xin Chen, Xiangkai Hao, Kaiyue Zhao, Xinglai Yuan, Mengru Li, Wen Yin, Shintaro Kobayashi, Shogo Kawaguchi, Bingbing Fan, Rui Zhang, Qilong Gao   +13 more
wiley   +1 more source