Results 41 to 50 of about 86,096 (306)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Teaching Military Cultural Competency to Clinicians and Clinical Students: Assessing Impact and Effectiveness

Journal of Community Engagement and Scholarship, 2022
Military members, veterans, and their families belong to a unique American subculture. Studies have identified the need for mental health professionals to attain military cultural competency to practice more effectively within this subculture.
Nancy Isserman, James A. Martin
doaj   +1 more source

The professional preparation of junior military officers in the Saudi Arabian National Guard : King Khaled Military Academy [PDF]

, 2003
This thesis is a contribution to cross-national studies of professional officer education and training. It describes and evaluates a junior officer preparation programme at King Khaled Military Academy (KKMA), Saudi Arabia, in a comprehensive way.
Al-Otaibi, Tha'ar
core  

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Honour, Masculinity and Corporality in the Officer Corps of Early Eighteenth-Century Sweden

Sjuttonhundratal, 2010
Military honour and physical commitment to serve king and fatherland played a central role in the ideals of the army of Charles XII of Sweden. These ideals were formed within a culture in which the role of the warrior, dictated by a code of honour, was ...
Ville Sarkamo
doaj   +1 more source

Integration of Euro-Atlantic Norms and Values: Changes in the Military Culture of the Balkans [PDF]

, 2010
In the recent past societies in the Balkan states have undergone profound changes during the period after the disintegration of Yugoslavia. The fragmentation of this previous regional power into a variety of successor states is the defining feature of ...
Rajkovcevski, Rade
core  

The South African military in transition : part 2 - from strategic culture to strategic reality [PDF]

, 2014
Please cita as follows: Louw, G. M. & Esterhuyse, A. 2014. The South African military in transition : part 2 - from strategic culture to strategic reality.
Louw, Gerhard M., Esterhuyse, Abel, Abel Esterhuyse, Gerhard M Louw   +3 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

The Bored Cossack: The Way of a Ukrainian Warrior

Faces of War
The article examines Ukrainian folk paintings of Cossack Mamai as the most complete visual archetype of the Cossack, a professional warrior of the Early Modern period.
Denys Toichkin
doaj   +1 more source

Unmet Healthcare Needs and Associated Factors Among Korean Enlisted Soldiers

, 2021
Introduction: The purpose of this study was to explore the rate of unmet healthcare needs among Korean enlisted soldiers and to examine the factors associated with unmet healthcare needs, based on Andersen's Health Service Behavior Model.
박정옥
core   +1 more source