Results 51 to 60 of about 86,096 (306)

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Problems of perception of militarism and military culture in modern civil society

Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Соціологічні дослідження сучасного суспільства: методологія, теорія, методи
The issues of modern perception by civil society of the phenomena of «military culture», «militarism», «militarization» in various socio-political circumstances are investigated and the trends of their spread and popularization in Ukrainian society are ...
Fedir Sandor, Marian Tokar
doaj   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

MILITARY CULTURE AND DEFENSE MANAGEMENT IN AZERBAIJAN: CONTEMPORARY TRANSFORMATIONS [PDF]

Journal of Defense Resources Management
The article is dedicated to studying military culture, which is of special relevance in military administration in modern times and acts as an important means of socialization between the army and society.
Naiba SHAMSHIYEVA
doaj  

TYPES AND STYLE OF MILITARY TEXTS USED IN FOREIGN LANGUAGE TEACHING [PDF]

Journal of Defense Resources Management, 2023
The article talks about the importance of teaching the culture of speech in military educational schools. One of the actual issues of teaching the culture of speech is the choice of style, the perfection of speech and the essence of the choice of ...
Nasibova Lutviya AKIF
doaj  

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

Advanced Science, EarlyView.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang, Wen Sun, Ting Xiao, Yali Wang, Xianlan Wu, Huiyou Chen, Ming Chen, Jun Zhang   +7 more
wiley   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

CULTURAL MODERATORS OF LEADERSHIP-RESILIENCE NEXUS: COMPARATIVE PERSPECTIVES FROM EASTERN AND WESTERN MILITARY INSTITUTIONS [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
The article explores how specific cultural dimensions influence the moderating relationship between authentic leadership and organizational resilience within military environments, contrasting institutional realities from Eastern Europe ...
CARAGEA MARIUS EMANUEL
doaj  

CHANGING MILITARY ORGANISATIONAL CULTURE - MULTIPLIER OF ORGANISATIONAL EFFECTIVENESS AND EFFICIENCY [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2023
Organisational culture is a reality, even in military organisations, that needs to be considered and constantly reflected upon in order to improve it. In this context, this study addresses the linkage of three organisational processes that are specific
RIZESCU ALEXANDRU-MARIUS
doaj  

The "war on terror" and the military-archaeology complex: Iraq, ethics, and neo-colonialism [PDF]

, 2009
The archaeological response to the 2003 invasion and occupation of Iraq is often portrayed as a crusade to rescue antiquities, destroyed either directly by the military action itself or indirectly by the looting of archaeological sites and museums.
Hamilakis, Yannis
core   +1 more source