Results 91 to 100 of about 556,594 (314)

TopCas: Topology‐Gated Cas12a via DNA‐RNA Chimeric Circular crRNA for Amplification‐Free Nucleic Acid Detection and Conditional Gene Editing

open access: yesAdvanced Science, EarlyView.
The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang   +7 more
wiley   +1 more source

External Interventions and Civil War Intensity in South-Central Somalia (1991-2010)

open access: yesCadernos de Estudos Africanos, 2014
External interventions in conflicts are prescribed to be peace-promoting mechanisms, but their effects seldom de-escalate conflict intensity. Based on the balance of capabilities theory, this paper tests the effects that the type of intervention ...
Ricardo Real Pedrosa de Sousa
doaj   +1 more source

COIN is dead - long live transformation [PDF]

open access: yes, 2012
Donald Rumsfeld was right. Force transformation works. The techniques that led to the initial victories in Afghanistan in 2001 were precisely those that produced success in Libya in 2011.1 Small-scale deployments of special forces backed by precision ...
Body, Howard   +2 more
core  

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu   +11 more
wiley   +1 more source

MODERN MILITARY ACTIONS AT THE BEGINNING OF THE 21st CENTURY [PDF]

open access: yesAnnals: Series on Military Sciences, 2019
The end of the 21st century finds the world in a great economic and political turmoil. On the one hand, the highly developed countries try to extend their influence outside the territorial borders to the resource-rich areas, on the other hand the ...
Gheorghe BOARU, Valerică PIROŞCĂ
doaj  

Efficacy and Safety of a Simple Auxiliary Liver Suspension Device in Complex Laparoscopic Hepatectomy: A Multicenter Randomized Clinical Trial

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Purpose To evaluate the efficacy and safety of a novel auxiliary liver suspension device in complex laparoscopic hepatectomy. Methods A total of 253 patients with hepatocellular carcinoma (HCC) undergoing complex laparoscopic hepatectomy at the Third Affiliated Hospital of Naval Medical University, Sichuan Provincial People's Hospital, and ...
Xiao‐Ying Zhu   +9 more
wiley   +1 more source

Les ressorts de l’intervention militaire tchadienne au Mali (2013)

open access: yesEchoGéo, 2013
This paper analyses the rationale behind the Chadian military intervention in Mali in 2013, which Chad is not a neighboring country, and whereas Chad is not an Ecowas member.
Géraud Magrin
doaj   +1 more source

Can Might Make Right? The Use of Force to Impose Democracy and the Arthurian Dilemma in the Modern Era [PDF]

open access: yes, 2008
US President George W. Bush used force to bring the Taliban to its knees and create a fledgling democracy in Afghanistan, then invaded Iraq with the end goal of establishing a democracy there, as well. Meanwhile, presidential hopeful Barack Obama praised
Thompson, Scott
core   +3 more sources

Deep Reinforcement Learning Approaches for Sensor Data Collection by a Swarm of UAVs

open access: yesAdvanced Intelligent Systems, EarlyView.
This article presents four decentralized reinforcement learning algorithms for autonomous data harvesting and investigates how collaboration improves collection efficiency. It also presents strategies to minimize training times by improving model flexibility, enabling algorithms to operate with varying number of agents and sensors.
Thiago de Souza Lamenza   +2 more
wiley   +1 more source

El cercano Oriente, estados y minorías étnico-nacionales.

open access: yesHistoria Crítica, 2003
The U.S. military intervention in Iraq has taken place in a región where states are artificial and historically recent creations that lack social homogeneity. The ethnic component (i.e., social groups whose identity is defined on the basis of one or more
Benjamín Herrera Chaves.
doaj  

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