Results 71 to 80 of about 556,594 (314)

Genocide [PDF]

open access: yes, 2014
Overview: Before the 1940s the word genocide did not exist. There was no name for unique mass killings involving thousands to millions of targeted people.
Johnson, Samantha
core   +1 more source

International Interventionism 1970-1989: A Count Data Approach [PDF]

open access: yes, 1996
Due to progress in statistical methods and improved data processing capabilities, count data modelling has become increasingly popular in the social sciences.
Geil, Peter, Rotte, Ralph
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang   +16 more
wiley   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

open access: yesAdvanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang   +13 more
wiley   +1 more source

Economic Determinants of Third-Party Intervention in Civil Conflict [PDF]

open access: yes
Our paper explores the economic conditions that lead third parties to intervene in ongoing internal wars. We develop a formal model that ties together some of the main forces driving the decision to interfere in a civil war, including the economic ...
Bove, Vincenzo, Sekeris, Petros
core   +3 more sources

Is There a Duty to Militarily Intervene to Stop a Genocide? [PDF]

open access: yes, 2016
Is there is a moral obligation to militarily intervene in another state to stop a genocide from happening (if this can be done with proportionate force)?
Steinhoff, Uwe
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

open access: yesAdvanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi   +15 more
wiley   +1 more source

Two Kinds of Change: Comparing the Candidates on Foreign Policy [PDF]

open access: yes, 2008
Few U.S. presidential elections have been decided on the basis of foreign policy. For the first time in decades, however, both parties have fielded candidates who have chosen to emphasize their foreign policy views.
Justin Logan
core  

Heterogeneous Wettability‐Based Construction of Two‐Phase Interfaces for Underwater Reversible Adhesion

open access: yesAdvanced Science, EarlyView.
The design employs heterogeneous wettability surfaces that construct stable oil‐water interfaces to achieve robust and rapid reversible adhesion. Linear enhancement of adhesion strength is realized through multi‐interface patterning. This adhesive enables rapid on‐demand detachment within five seconds via voltage‐induced electrolysis, offering a level ...
Xiaokai Li   +11 more
wiley   +1 more source

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