Results 51 to 60 of about 68,205 (265)
Advanced Science, EarlyView.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source
مجلة القانون، المجتمع والسلطةInternational intervention remains a complex and contentious element of U.S. foreign policy, with the 2011 U.S. military intervention in Libya standing out as a pivotal moment in international relations.
Amina M’lili
doaj +1 more source
THE POLITICS OF ARMS TRADE: THE “FORGOTTEN WAR” IN YEMEN [PDF]
Journal of Defense Resources Management, 2018 This paper focuses on the political implications of the arms trade and transfers related to the conflict in Yemen, wishing to emphasize the nature and the impact of arms exports to states involved in ongoing military conflict to both the outcome of the
Raluca-Elena RĂDUCEA
doaj
La “Prueba del esfuerzo personal” en la teoría de la intervención militar de Michael Walzer
Co-herencia: Revista de Humanidades, 2019 This paper analyzes the importance of Michael Walzer’s self-help test and discusses its importance as a link between a community’s internal con-flict and foreign military intervention.
Miguel Paradela
doaj +1 more source
Advanced Science, EarlyView.A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo +5 more
wiley +1 more source
Advanced Science, EarlyView.The phase transition of supercritical CO2 induces the foaming of dense MXene film without compromise inherent structure of MXene nanosheet. The foamed porous MXene film manifests remarkable EMI shielding and infrared thermal camouflage performances. Moreover, the foaming strategy is broadly adaptable and can be extended to other two‐dimensional films ...
Hui Zhao +7 more
wiley +1 more source
Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction
Advanced Science, EarlyView.This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng +12 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
wiley +1 more source
Securitising public health emergencies: a qualitative examination of the origins of military intervention in Sierra Leone's Ebola Epidemic. [PDF]
BMJ Public Health, 2023 Boland ST, Mayhew S, Balabanova D.
europepmc +1 more source
REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma
Advanced Science, EarlyView.Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source