Results 31 to 40 of about 706,597 (312)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Big business with Chinese characteristics: two paths to growth of the firm in China under reform [PDF]

, 2001
This paper presents a case study of two large firms which emerged from among the ranks of traditional state-owned enterprises and new entrants: Shougang (steel) and Sanjiu (pharmaceuticals).
Nolan, P, Yeung, Godfrey
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

mRNA-based platform for preventing and treating Staphylococcus aureus by targeted staphylococcal enterotoxin B

Frontiers in Immunology
Staphylococcus aureus (S. aureus) possesses numerous virulence factors, with the increasing prevalence of drug-resistant strains heightening the threat posed by this pathogen.
Fumei Luo, Fumei Luo, Chuanfei Xu, Chengwen Zhang, Aomo Tan, Dongshui Lu, Ping Luo, Ping Cheng, Weijun Zhang, Lijuan Bai, Cuiyun Yu, Si Sun, Hao Zeng, Quanming Zou   +13 more
doaj   +1 more source

Life Cycle of a Military Product [PDF]

Scientific Bulletin, 2018
Abstract Romania’s membership of the select group of states belonging to the North Atlantic Treaty Organization brings, in addition to the expected security benefits and assurances and commitments and obligations that we have to assume. The participation of politicians, militaries and Romanian experts in the decision-making within the
openaire   +2 more sources

Security: Collective good or commodity? [PDF]

, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2008 Sage.The state monopoly on the legitimate use of violence in Europe and North America has been central to the development of security
Briggs, Rachel, Business Wire, Buzan, Barry, Buzan, Barry, Committee on Oversight and Government Reform, Dabelko, Geoffrey D., Elke Krahmann, Ericson, Richard V., Financial Times, Foldvary, Fred, GAO, GAO, GAO (Government Accountability Office, Gleick, Peter H., Hartley, Keith, Johnston, Les, Jones, Trevor, Kinsey, Christopher, Kirchner, Emil, Kirchner, Emil, Krause, Keith, Lilly, Damian, Lipschutz, Ronnie, Mandel, Robert, McCarthy, Ellen, Merle, Renae, NATO, Parfomak, Paul W., Reuters, Rothschild, Emma, Sandler, Todd, Singer, Peter W., South, Nigel, Spinner, Jackie, Spinner, Jackie, Spinner, Jackie, The Associated Press, United Nations, US Department of State, US Department of State, Weiner, Tim, White House, White House, Witter, Willis   +43 more
core   +2 more sources

Receptor‐Free Identification of Toxic Gases Enabled by Hygroscopic Aqueous Salt Films

Advanced Functional Materials, EarlyView.
Water as a gas sensor coating sounds impossible—until it stops evaporating. Here, hygroscopic salt solutions (LiCl, LiBr, H3PO4) form non‐drying aqueous films on CNT chemiresistors under ambient air. Gases partition into these liquid layers, sometimes transforming into water, and generate salt‐specific resistance fingerprints across a four‐channel ...
Seongwoo Lee, Yun‐Tae Kim, Hwarang Choi, Sanghwan Park, Seongyeop Lim, Chang Young Lee   +5 more
wiley   +1 more source

Rational Design of a Chimeric Derivative of PcrV as a Subunit Vaccine Against Pseudomonas aeruginosa

Frontiers in Immunology, 2019
Pseudomonas aeruginosa (PA) is a major cause of nosocomial infections, which remain an unsolved problem in the clinic despite conventional antibiotic treatment. A PA vaccine could be both an effective and economical strategy to address this issue.
Chuang Wan, Jin Zhang, Jin Zhang, Liqun Zhao, Xin Cheng, Chen Gao, Ying Wang, Wanting Xu, Wanting Xu, Quanming Zou, Jiang Gu   +10 more
doaj   +1 more source

Ensuring technological independence by creating the necessary reserves of the electronic component base as one of the elements of its power of attorney

Безопасность информационных технологий, 2023
The wars of the new information age impose higher requirements for the introduction of automatic control systems with artificial intelligence elements of modern weapons, and the current stage of the use of weapons and military equipment dictates the need
Roman N. Zhurikov, Ilya S. Shchukin, Yaroslav N. Yushkov   +2 more
doaj   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source