Results 131 to 140 of about 4,298,144 (311)

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

open access: yesAdvanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao   +10 more
wiley   +1 more source

Eliot Cohen visit to VMI, March 10, 2017

open access: yes, 2017
Eliot Cohen, professor of Strategic Studies at Johns Hopkins University’s School of Advanced International Studies and author of “The Big Stick: the Limits of Soft Power and the Necessity of Military Force,” visited Lt. Col.
VMI Communications and Marketing (photographer);
core  

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

open access: yesAdvanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen   +12 more
wiley   +1 more source

A. Daryl Hooker Interview

open access: yes, 2005
Arbury Daryl Hooker was drafted in June of 1969 into the U.S. Army Special Forces and served with Project Phoenix during the Vietnam War (1970-1973). During his military career he was stationed in Korea from 1973-1974, Ft.
Hooker, A. Daryl
core  

The strategy of Ukrainian - U.S. defense and military relations on the modern stage [PDF]

open access: yes, 2003
This thesis analyses the strategy of modern Ukrainian - U.S. defense and military relations in three areas: Defense Relations; Military Relations; and Civil-Military Relations.
Verbytskyi, Serhii
core  

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han   +11 more
wiley   +1 more source

James R. Cook Interviews

open access: yes, 2005
Two interviews with U. S. Army officer R. James Cook. Cook was on active duty with the United States Army for over 20 years - first as an enlisted soldier, E2-E6; and subsequently as an officer, 2LT - MAJ.
Cook, James R.
core  

Noninvasive Detection and Subtyping of Esophageal Cancer by Circulating Cell‐Free mtDNA Fragmentomics: A Multi‐Center Validation Study

open access: yesAdvanced Science, EarlyView.
Circulating cell‐free mitochondrial DNA provides a robust, noninvasive platform for early detection and histological subtyping of esophageal cancer. This large multi‐center study validates consistently high accuracy across ethnically and geographically diverse cohorts, demonstrating strong potential to transform clinical management. ABSTRACT Esophageal
Yue Liu   +15 more
wiley   +1 more source

William Flanagan Interview

open access: yes, 2010
Admiral Flanagan commissioned in 1967 and was selected for flag rank in his 20th year of service; he was subsequently among the youngest officers to achieve four star rank. During his 29 year career he served in all theaters of operations, including the
Flanagan, William J.
core  

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

open access: yesAdvanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim   +12 more
wiley   +1 more source

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