Results 111 to 120 of about 8,449,269 (337)

Debating US Military Strategy in the Persian Gulf: What is the Way Forward?

open access: yesRevista Brasileira de Política Internacional, 2018
Should the US strategy toward the Gulf be one of offshore balancing or one of deep engagement? The debate on US grand strategy lacks solid empirical ground. I address this issue by providing a study of the US´ role as the Gulf’s security provider.
Eugenio Lilli
doaj   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng   +5 more
wiley   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang   +10 more
wiley   +1 more source

The southern flank of NATO, 1951-1959: military stategy or poltical stabilisation?

open access: yes, 2010
PhDIn 1951-52, the North Atlantic Treaty Organisation established the Southern Flank, a strategy for the defence of the eastern Mediterranean in the Cold War involving Greece, Italy and Turkey.
Chourchoulis, Dionysios
core  

Full spectrum defence: re-thinking the fundamentals of Australian defence strategy [PDF]

open access: yes, 2015
This report argues that successive Australian governments have failed to define an effective national defence strategy. Executive summary Australia’s inability to clearly and succinctly define its defence strategy is a perennial failing that will have ...
Alan Dupont
core  

THE DIMENSIONS OF MILITARY STRATEGY

open access: yesThe US Army War College Quarterly: Parameters, 1977
Abstract : This memorandum considers the nature of military strategy, and how it overlaps with tactics and national (grand) strategy. Five approaches which offer varying perspectives to strategic problems are identified and discussed. These are: the classical (or historic) approach; the spatial approach; the power potential approach; the technological ...
openaire   +3 more sources

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

open access: yesAdvanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang   +10 more
wiley   +1 more source

The general as statesman : exploring the professional need for commanders to support viable political outcomes in peace and stability operations as typified by the UK military approach [PDF]

open access: yes, 2011
The problem of theatre level politico-military arrangements during peace and stability operations is important because the intervening actors, working in complex and often ambiguous circumstances, need to calibrate the application of military and ...
Lovelock, R.
core  

Implication of a (military) strategy on the operational art

open access: yes, 2017
At the beginning of the 21st century, the theory of defense (military science) in the Republic of Serbia was at a crossroads after the sudden turn from the Eastern (the so-called Russian) to the Western (the so-called American) standpoint.
Slavković Rade, Talijan Miroslav
core   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao   +8 more
wiley   +1 more source

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