Results 101 to 110 of about 1,019,616 (311)

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

open access: yesAdvanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li   +12 more
wiley   +1 more source

Analysis of core abilities and supporting techniques in joint all-domain command and control [PDF]

open access: yesZhihui kongzhi yu fangzhen
In order to push forward “The Third Offset Strategy” and enhance the ability of globally integrated operations, the U.S military proposes all-domain command and control (JADC2).
SHAN Hongchang, WU Lin
doaj   +1 more source

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

open access: yesAdvanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet   +8 more
wiley   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

open access: yesAdvanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu   +20 more
wiley   +1 more source

Advanced composite airframe program: Today's technology [PDF]

open access: yes
The Advanced Composite Airframe Program (ACAP) was undertaken to demonstrate the advantages of the application of advanced composite materials and structural design concepts to the airframe structure on helicopters designed to stringent military ...
Good, Danny E., Mazza, L. Thomas
core   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

open access: yesAdvanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao   +6 more
wiley   +1 more source

Organizational form of control military-technical policy of Ukraine

open access: yesAspekti Publìčnogo Upravlìnnâ, 2014
In the article the new organizational forms of state administration are offered by a military-technical policy, that before in Ukraine was not used, and that today must be examined as main descriptions of the system of state administration.
O. F. Saljnikova
doaj  

Modeling and Simulation for Effectiveness Evaluation of Dynamic Discrete Military Supply Chain Networks

open access: yesComplexity, 2017
The effectiveness of military supply chain networks is an important reference for logistics decision-making, and it is crucial to evaluate it scientifically and accurately.
Biao Xiong   +4 more
doaj   +1 more source

Dynamic Decoration of DNA Scaffolds for High‐Resolution Cancer Cell Subtyping

open access: yesAdvanced Science, EarlyView.
This study presents a dual‐mode imaging platform that utilizes self‐assembly and disassembly of DNA scaffolds for high‐resolution cancer cell detection. The structural rigidity of DNA scaffolds effectively prevents cellular internalization for over 300 min.
Xiaolin Hu   +15 more
wiley   +1 more source

A Bourdieusian Analysis of U.S. Military Culture Ground in the Mental Help-Seeking Literature

open access: yesAmerican Journal of Men's Health, 2017
This theoretical treatise uses the scientific literature concerning help seeking for mental illness among those with a background in the U.S. military to posit a more complex definition of military culture.
Traci Abraham PhD   +2 more
doaj   +1 more source

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