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A Perspective on Interactive Theorem Provers in Physics

open access: yesAdvanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

open access: yesAdvanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su   +10 more
wiley   +1 more source

Bioinspired Microreactor for Iodide Adsorption and Photooxidation Recovery

open access: yesAdvanced Science, EarlyView.
A bioinspired micro‐ionic‐reactor based on porous organic polymer (MIR‐POP) integrates rapid iodide capture with in situ photooxidative conversion, achieving record uptake capacity and high uptake efficiencies in simulated mining wastewater and natural brine. This bioinspired microreactor strategy offers a new avenue for sustainable iodine recovery and
Xuewen Cao   +8 more
wiley   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

open access: yesAdvanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu   +10 more
wiley   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng   +9 more
wiley   +1 more source

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