Results 51 to 60 of about 269,885 (314)

The Content of African Diets is Adequate to Achieve Optimal Efficacy with Fixed-Dose Artemether-Lumefantrine: A Review of the Evidence. [PDF]

, 2008
A fixed-dose combination of artemether-lumefantrine (AL, Coartem(R)) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falciparum.
Nathan Mulure, Abdulla, Salim, Kokwaro, Gilbert, Salim Abdulla, Mulure, Nathan, Ndong, A, Zulfiqarali G Premji, Ndong, A., Alice Ndong, Gilbert Kokwaro, Abdulla, S., Ndong, Alice, Mulure, N., Nwaiwu, Obiyo, Premji, Zul, Nwaiwu, O., Ogutu, Bernhards, Falade, C.O., Premji, Zulfiqarali G, Falade, Catherine O, Catherine O Falade, Sagara, Issaka, Sagara, I., Obiyo Nwaiwu, Ogutu, B., Bernhards Ogutu, Premji, Z.G., Kokwaro, G., Issaka Sagara   +28 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Milk, coronary heart disease and mortality [PDF]

, 2001
<b>STUDY OBJECTIVE</b> To study the association between reported milk consumption and cardiovascular and all cause mortality. <b>DESIGN</b> A prospective study of 5765 men aged 35-64 at the time of examination.
Davey Smith, G., Hart, C.L., Ness, A.
core   +1 more source

Milk Composition Traits of Hamdani Crossbreed Sheep Raised Under Extensive Management

ISPEC Journal of Agricultural Sciences, 2023
This study aimed to reveal the milk composition traits of Hamdani crossbred sheep (Hcs) raised under extensive conditions. A total of 96 sheep milk samples were collected during the early lactation stage.
Ali Osman TURGUT, Erman GÜLENDAĞ, Davut KOCA, Sefa ÜNER   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Fat source and dietary forage-to-concentrate ratio influences milk fatty-acid composition in lactating cows

Animal, 2014
On the basis of the potential benefits to human health there is an increased interest in producing milk containing lower-saturated fatty acid (SFA) and higher unsaturated fatty acid (FA) concentrations, including cis-9 18:1 and cis-9, trans-11-conjugated
M. Vazirigohar, M. Dehghan-Banadaky, K. Rezayazdi, S.J. Krizsan, A. Nejati-Javaremi, K.J. Shingfield   +5 more
doaj   +1 more source

A Study on Milk Compositions of Hair Goat and Saanen x Hair Goat Crossbreed (F1) under Semi-Intensive Conditions

Journal of Agricultural Sciences, 2021
This study was carried out to evaluate compositions of milk from Hair goat and Saanen x Hair goat crossbreed (F1) under semi-intensive conditions. The research was conducted on 20 Hair goats and 20 Saanen x Hair goat crossbreed (F1) at Farm for Research ...
Orhan Yılmaz, Bahattin Çak, Elvan Ocak, Ahmet Fatih Demirel   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The Host Defense Proteome of Human and Bovine Milk

, 2011
Milk is the single source of nutrients for the newborn mammal. The composition of milk of different mammals has been adapted during evolution of the species to fulfill the needs of the offspring.
Hooijdonk, A.C.M., van, Jacques Vervoort, Boeren, S., Hein van Valenberg, van Hooijdonk, A.C.M., Vervoort Jacques, van Valenberg Hein, Sacco de Vries, de Vries Sacco, Boeren Sjef, Hettinga Kasper, Vries, S.C., de, Valenberg, H.J.F., van, Hettinga, K.A., van Hooijdonk Toon, Kasper Hettinga, Sjef Boeren, de Vries, S.C., Arendonk, J.A.M., van, Toon van Hooijdonk, Johan van Arendonk, van Arendonk, J.A.M., van Arendonk Johan, Vervoort, J.J.M., van Valenberg, H.J.F.   +24 more
core   +1 more source